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Risk
of cancer among relatives of patients with glioma
O'Neill
BP, Blondal H, Yang P, Olafsdottir GH, Sigvaldason H, Jenkins RB,
Kimmel DW, Scheithauer BW, Rocca WA, Bjornsson J, Tulinius H
Department
of Neurology, and the Mayo Clinic Cancer Center, Rochester Minnesota
55905, USA.
boneill@mayo.edu
We
report a population-based, retrospective study of 396 Icelandic people
diagnosed with glioma in the years 1940-1995.
The purpose of this study was to test whether astrocytomas, other
glial tumors, other central nervous system tumors, or other cancers
aggregate in families identified through glioma probands who were of
Icelandic origin.
Pedigrees of the 396 cases were traced by the Genetical Committee of
the University of Iceland and linked to the Icelandic Cancer Registry.
A total of 25,546 relatives, including 2,080 individuals with cancer
were identified within these pedigrees.
There was no statistically significant increase of glioma in relatives
of glioma patients, nor was there any statistically significant
increase in risk for other central nervous system tumors.
There was no overall increase in incidence of all cancer combined, nor
of specific common cancers (lung, prostate, breast, stomach, and
colorectal) and uncommon cancers (melanoma and pancreas) in the
relatives of glioma patients.
Our results do not support the hypothesis of a familial aggregation of
glioma indicative of a glioma susceptibility gene.
PMID: 12223439 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12223439&dopt=Abstract
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