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Cancer
incidence in families with multiple glioma patients
Paunu N, Pukkala E, Laippala P, Sankila R, Isola J, Miettinen H, Simola KO,
Helen P, Helin H, Haapasalo H
Department of Pathology, Tampere University Hospital, Tampere,
Finland
Twenty-four Finnish families with 2 or more glioma patients were identified
through questionnaires sent to 369 consecutive glioma patients receiving surgery
at Tampere University Hospital during 1983-94.
To explore whether unusual cancer susceptibility is involved, the cancer risk of
2,664 family members was estimated using population-based data from the Finnish
Cancer Registry.
Among the total cohort of relatives, 88 cancers were observed during
1953-97.
The overall cancer risk among 12 families with juvenile onset gliomas was
significantly decreased (standardized incidence ratio [SIR] 0.6, 95% confidence
interval [CI]: 0.4-0.9).
Among 12 families with adult onset gliomas, the overall cancer risk was equal to
that of the reference population (SIR 1.1, 95% CI: 0.8-1.4) whereas the risk of
skin melanoma (SIR 4.0, 95% CI: 1.5-8.8) and meningioma (SIR 5.5, 95% CI:
1.1-16) were significantly increased.
Several other tumors, including those associated with neurofibromatosis 1 and 2,
tuberous sclerosis and Li-Fraumeni and Turcot syndromes were surveyed, but no
elevated risks were observed.
In conclusion, the presence of meningiomas and skin melanomas in glioma families
may indicate a novel association as a cancer susceptibility trait.
Copyright 2001 Wiley-Liss, Inc.
PMID: 11857361 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11857361&dopt=Abstract
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