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Radiotherapy-induced cerebral
abnormalities in patients with low-grade glioma
T. J. Postma, MD,
M. Klein, PhD, C. C.P. Verstappen, MD, J.
E.C. Bromberg, MD, M. Swennen, MD, J. A.
Langendijk, MD, M. J.B. Taphoorn, MD, P.
Scheltens, MD, B. J. Slotman, MD, H. M. van
der Ploeg, PhD, N. K. Aaronson, PhD and J.
J. Heimans, MD
From the Departments of Neurology
(Drs. Postma, Verstappen, Scheltens, and Heimans), Medical Psychology
(Drs. Klein, van der Ploeg, and Aaronson), and Radiation Oncology
(Drs. Langendijk and Slotman), Vrije Universiteit Medical Center,
Amsterdam; Department of Neurology (Drs. Bromberg, Swennen, and
Taphoorn), University Medical Center, Utrecht; Department of
Psychosocial Research and Epidemiology (Dr. Aaronson), The Netherlands
Cancer Institute, Amsterdam, the Netherlands. Address correspondence
and reprint requests to T.J. Postma, MD, Dept. of Neurology, Vrije
Universiteit Medical Center, P.O. Box 7057, 1007 MB Amsterdam, the
Netherlands; e-mail: TJ.Postma@vumc.nl.
Abnormalities on CT or MRI and
neuropsychological performance in patients with low-grade
glioma, with (n = 23) or without (n = 16) prior cerebral
radiotherapy, were evaluated.
Cerebral atrophy was observed in 14 of 23 patients (61%)
treated with prior radiotherapy, and in 1 of 16 patients
(6%) without prior radiotherapy.
White matter abnormalities were observed in six patients,
all of whom were treated with prior radiotherapy.
These radiologic cerebral abnormalities correlated with cognitive
performance.
© 2002 American Academy of
Neurology
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