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Differentiation
of radiation necrosis from tumor progression using proton magnetic resonance
spectroscopy
Schlemmer
HP, Bachert P, Henze M, Buslei R, Herfarth KK, Debus J, van KG
Research
Program Radiological Diagnostics and Therapy, Deutsches Krebsforschungszentrum (DKFZ),
Heidelberg, Germany. h.schlemmer@dkfz-heidelberg.de
We
report on a young woman who was treated by stereotactic radiotherapy for
recurrence of an initially resected low-grade astrocytoma.
MRI follow-up examination 7 months after radiotherapy showed a gadolinium-DTPA-enhancing
mass lesion indicative of high-grade tumor progression.
This assumption was also supported by positron emission tomography with
[2-18F]fluoro-2-deoxy-D-glucose (FDG-PET). In contrast, proton MR spectroscopy
(1H-MRS) indicated radiation necrosis, which was confirmed histopathologically
in surgical specimens.
Subsequent follow-up examinations up to 19 months after surgery showed no
evidence of tumor recurrence.
PMID: 11942375 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11942375&dopt=Abstract
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