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Quality
of life (QOL) and sexual function in brain tumor (BT) patients
Elene T
Viscosi, Marlene B Goldman, Ronghui Xu, Nancy Bailey, Donna DelloIacano, Andrew
Lee, Peter M Black, Patrick Y Wen
Dana-Farber
Cancer Inst, Boston, MA; Beth Israel Deaconess Medcl Ctr, Boston, MA; Brigham
and Women's Hospital, Boston, MA
Although
the long term cognitive complications of radiotherapy (RT) are well known, there
is little information about other QOL issues, including sexual dysfunction, in
medium and long-term survivors of BT.
Three questionnaires were administered to two groups of adult BT patients with
stable disease.
Pituitary tumors were excluded.
One group completed RT at least one year previously (median time from RT 31
months).
A second group received no RT.
Patients' QOL measures included: Functional Assessment of Cancer Therapy-Brain
(FACT-BR), Beck Depression Inventory (BI), and a sexual function questionnaire.
Statistical analysis was performed using Fisher's exact test, two-sample t-test,
and multiple linear regression.
There were 74 RT patients (16 benign tumors, 25 low-grade gliomas (LGG), 24
high-grade gliomas, 8 metastases, 1 unknown) and 55 non-RT patients (34 benign
tumors, 19 LGG, 2 others).
Frequency of depression in the RT and non-RT groups was mild 79.7%/78.2%,
moderate 12.2%/14.5% and severe 8.1%/7.3%.
Frequency of menstrual and sexual dysfunction in the RT and non-RT were:
WOMEN-amenorrhea 24%/10.7%, menstrual irregularities 56%/28.6%, decreased sexual
interest 39.4%/38.2%, decreased frequency of sex 45.8%/38.5%, sexual dysfunction
16.1%/12.5%, and decreased orgasm 20.8%/25%; MEN-decreased interest 30.8%/25%,
decreased frequency of sex 52%/35.7%, impotence 21.6%/17.6% and ejaculation
difficulties 18.9%/0%.
Multiple correlation coefficient between BI score and sexual dysfunction was
0.28 in women and 0.14 in men.
There was no statistical difference between RT and non-RT groups in frequency of
depression and FACT-BR QOL subsets.
Sexual dysfunction appears to be more frequent in the RT group, but the
difference did not reach statistical significance, possibly because of the
relatively small number of patients.
Menstrual irregularities were slightly more common in RT patients (p=0.055).
This study suggests that sexual dysfunction and depression are common in BT
patients.
© Copyright 2002
American
Society of Clinical Oncology
Source:
http://www.asco.org/ac/1,1003,_12-002324-00_18-002002-00_19-00291-00_29-00A-00_42-00ONeill-00_43-00-00_44-00-00_45-00
Author-00_46-00Title-00_47-00Title-00_48-00and-00_49-00and,00.asp?cat=CNS+Tumors&parent=CENTRAL+NERVOUS+SYSTEM+TUMORS
&returnpid=2323
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