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Acetazolamide
therapy for symptomatic plateau waves in patients with brain tumors. Report of
three cases
Watling CJ, Cairncross JG.
Department of Clinical Neurological Sciences, University of Western Ontario,
London, Canada. Chris.Watling@LHSC.ON.CA
In this report, the authors describe three patients with malignant gliomas who
experienced paroxysmal neurological symptoms triggered by standing.
The symptoms were attributed to acute elevations of intracranial pressure, an
uncommon phenomenon called "plateau waves."
In each instance, the attacks occurred despite the fact that the patient was
receiving dexamethasone therapy and stopped promptly with the addition of
acetazolamide.
Acetazolamide, an orally administered carbonic anhydrase inhibitor, appears to
be a specific and effective therapy for this uncommon neurological disorder.
PMID: 12134920 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12134920&dopt=Abstract
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