Treatment > Treatment Surveys  


Fairview Press, 2450 Riverside Ave. Minneapolis, MN 55454, www.fairviewpress.org ; August 2002. (Book, References)

Surviving "Terminal" Cancer: Clinical Trials, Drug Cocktails, and Other Treatments Your Doctor Won't Tell You About

Ben Williams, PhD

REFERENCES

Chapter 1 - Diagnosis: Glioblastoma multiforme "The Terminator" [1] Eric C. Holland
Glioblastoma multiforme: The terminator

Proc. Natl. Acad. Sci. USA
, Vol. 97, Issue 12, 6242-6244, June 6, 2000 (Commentary, Full Text)

[2] N.A.

Chapter 2 - Searching for Treatment [1] Wilson CB
Glioblastoma: the past, the present, and the future

Clin Neurosurg 1992;38:32-48
(Review Article, Reference)

[2] Hatanaka H, Nakagawa Y.
Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy

Int J Radiat Oncol Biol Phys 1994 Mar 30;28(5):1061-6 (Clinical Study, Abstract)

[3] Coderre JA, Elowitz EH, Chadha M, Bergland R, Capala J, Joel DD, Liu HB, Slatkin DN, Chanana AD.
Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results
J Neurooncol 1997 May;33(1-2):141-52 (Clinical Study, Abstract)

[4] N.A.

[5] Glantz MJ, Cole BF, Friedberg MH, Lathi E, Choy H, Furie K, Akerley W, Wahlberg L, Lekos A, Louis S
A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors
Neurology 1996 Apr;46(4):985-91 (Clinical Study, Abstract)

[6] Salazar AM, Levy HB, Ondra S, Kende M, Scherokman B, Brown D, Mena H, Martin N, Schwab K, Donovan D, Dougherty D, Pulliam M, Ippolito M, Graves M, Brown H, Ommaya A.
Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study
Neurosurgery 1996 Jun;38(6):1096-103 (Clinical Study, Abstract)

[7] Couldwell WT, Weiss MH, DeGiorgio CM, Weiner LP, Hinton DR, Ehresmann GR, Conti PS, Apuzzo ML.
Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen
Neurosurgery 1993 Mar;32(3):485-9 (Clinical Study, Abstract)

[8] Zhang W, Yamada H, Sakai N, Niikawa S, Nozawa Y.
Enhancement of radiosensitivity by tamoxifen in C6 glioma cells

Neurosurgery 1992 Oct;31(4):725-9 (
Cell Culture Study
[9] Mastronardi L, Puzzilli F, Couldwell WT, Farah JO, Lunardi P.
Tamoxifen and carboplatin combinational treatment of high-grade gliomas. Results of a clinical trial on newly diagnosed patients
J Neurooncol 1998 May;38(1):59-68 (Clinical Study, Abstract)

[10] Barker FG 2nd, Prados MD, Chang SM, Gutin PH, Lamborn KR, Larson DA, Malec MK, McDermott MW, Sneed PK, Wara WM, Wilson CB.
Radiation response and survival time in patients with glioblastoma multiforme
J Neurosurg 1996 Mar;84(3):442-8 (Clinical Study, Abstract)

[11] Fernandez PM, Zamorano L, Yakar D, Gaspar L, Warmelink C.
Permanent iodine-125 implants in the up-front treatment of malignant gliomas
Neurosurgery 1995 Mar;36(3):467-73 (Clinical Study, Abstract)

[12] Halligan JB, Stelzer KJ, Rostomily RC, Spence AM, Griffin TW, Berger MS.
Operation and permanent low activity 125I brachytheraphy for recurrent high-grade astrocytomas
Int J Radiat Oncol Biol Phys 1996 Jun 1;35(3):541-7 (Clinical Study, Abstract)


Chapter 3 - Improving My Odds for Survival [1] Levin VA, Prados MR, Wara WM, Davis RL, Gutin PH, Phillips TL, Lamborn K, Wilson CB
Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas
Int J Radiat Oncol Biol Phys 1995 Apr 30;32(1):75-83 (
Clinical Study, Abstract)

[2] Figueredo A, Arnold A, Goodyear M, Findlay B, Neville A, Normandeau R, Jones A
Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer. A phase I/II study
Cancer 1990 May 1;65(9):1895-902 (Clinical Study, Abstract)

[3] Bowles AP Jr, Pantazis CG, Wansley W
Use of verapamil to enhance the antiproliferative activity of BCNU in human glioma cells: an in vitro and in vivo study
J Neurosurg 1990 Aug;73(2):248-53 (Cell Culture Study | Animal Study, Abstract)

[4] Aas AT, Brun A, Pero RW, Salford LG.
Chlorpromazine in combination with nitrosourea inhibits experimental glioma growth
Br J Neurosurg 1994;8(2):187-92 (Cell Culture Study, Abstract)

[5], [6] N.A.

[7] Murovic J, Turowski K, Wilson CB, Hoshino T, Levin V
Computerized tomography in the prognosis of malignant cerebral gliomas
J Neurosurg 1986 Dec;65(6):799-806 (Clinical Study, Abstract)

[8] Lissoni P, Meregalli S, Nosetto L, Barni S, Tancini G, Fossati V, Maestroni G.
Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone
Oncology 1996 Jan-Feb;53(1):43-6 (
Clinical Study, Abstract)

[9] Das UN, Prasad VV, Reddy DR
Local application of gamma-linolenic acid in the treatment of human gliomas
Cancer Lett 1995 Aug 1;94(2):147-55 (Clinical Study, Abstract)


Chapter 4 - Salvaging a Life N.A.

Chapter 5 - Toward a Rational Treatment Strategy [1] Rowlands MG, Budworth J, Jarman M, Hardcastle IR, McCague R, Gescher A
Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues

Biochem Pharmacol 1995 Aug 25;50(5):723-6
(Cell Culture Study, Abstract)

[2], [3], [4], [5] N.A.

[6] HA Fine, JS Loeffler, A Kyritsis, P Wen, PM Black, VA Levin, S Graham, WKA Yung
A phase II trial of the anti-angiogenic agent, thalidomide, in patients with recurrent high-grade gliomas

ASCO Proceedings, 1997 Annual Meeting, Abstract No. 1372 (Clinical Study)


[7] Jo Glass, Gruber Michael , Anit Nirenberg
Phase I/II Study of Carboplatin and Thalidomide in Recurrent Glioblastoma Multiforme
ASCO Proceedings, 1999 Annual Meeting, Abstract
No. 551 (Clinical Study)


Chapter 6 - Shared Experiences [1], [2] N.A.

[3] Plowman J, Waud WR, Koutsoukos AD, Rubinstein LV, Moore TD, Grever MR
Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea
Cancer Res 1994 Jul 15;54(14):3793-9 (Animal Study, Abstract)


[4] Newlands ES, O'Reilly SM, Glaser MG, Bower M, Evans H, Brock C, Brampton MH, Colquhoun I, Lewis P, Rice-Edwards JM, Illingworth RD, Richards PG.
The Charing Cross Hospital experience with temozolomide in patients with gliomas

Eur J Cancer 1996 Dec;32A(13):2236-41
(Clinical Study, Abstract)


Chapter 7 - Conventions of the Medical System and Their Ramifications [1], [2], [3], [4] N.A.
[5] Yung WK, Kyritsis AP, Gleason MJ, Levin VA
Treatment of recurrent malignant gliomas with high-dose 13-cis-retinoic acid
Clin Cancer Res 1996 Dec;2(12):1931-5 (Clinical Study, Abstract)

[6] N.A.


Chapter 8 - Arbitrary Policies Exclude Promising Treatment [1] Laperriere NJ, Leung PM, McKenzie S, Milosevic M, Wong S, Glen J, Pintilie M, Bernstein M
Randomized study of brachytherapy in the initial management of patients with malignant astrocytoma
Int J Radiat Oncol Biol Phys 1998 Jul 15;41(5):1005-11 (Clinical Study, Abstract)

[2] Brem H, Piantadosi S, Burger PC, Walker M, Selker R, Vick NA, Black K, Sisti M, Brem S, Mohr G, et al.
Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group
Lancet 1995 Apr 22;345(8956):1008-12 (Clinical Study, Abstract)

[3] N.A.

[4] R Albright, M Brada, J Brunner, MH Dugan, K Fink, R Fredericks, VA Levin, J Olson, M Prados, A Spence, N Yue, A Yung, S Zaknoen
Randomized Trial of Temodal (TEM) Vs. Procarbazine (PCB) in Glioblastoma Multiforme (GBM) at First Relapse
ASCO Proceedings, 1999 Annual Meeting, Abstract
(Clinical Study)

[5] Yung WK, Prados MD, Yaya-Tur R, Rosenfeld SS, Brada M, Friedman HS, Albright R, Olson J, Chang SM, O'Neill AM, Friedman AH, Bruner J, Yue N, Dugan M, Zaknoen S, Levin VA.
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group
J Clin Oncol 1999 Sep;17(9):2762-71 (Clinical Study, Abstract)

[6a] M Brada, DG Thomas, NM Bleehen, JT Roberts, F Senanayake, P Abram, PL Lantos, TH Moss, JW Ironside, JB Whaley, SP Stenning
Medical Research Council (MRC) Randomised Trial of Adjuvant Chemotherapy in High Grade Glioma (HGG)

ASCO Proceedings, 1998 Annual Meeting, Abstract No. 1543
(Clinical Study)

[6b] Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP
Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults

Cancer 1993 Apr 15;71(8):2585-97 (Evaluation Study, Abstract)

[7] Couldwell WT, Weiss MH, DeGiorgio CM, Weiner LP, Hinton DR, Ehresmann GR, Conti PS, Apuzzo ML.
Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen
Neurosurgery 1993 Mar;32(3):485-9 (
Clinical Study, Abstract)
[8] Vertosick, F.T., and Selker, R.G.
The treatment of newly diagnosed glioblastoma multiforme using high dose tamoxifen (TMX), radiotherapy and convenzional chemotherapy

AACR Proceedings, 1997 Annual Meeting, Abstract No. 2887 (Clinical Study)

[9] Yung WK, Kyritsis AP, Gleason MJ, Levin VA
Treatment of recurrent malignant gliomas with high-dose 13-cis-retinoic acid
Clin Cancer Res 1996 Dec;2(12):1931-5 (Clinical Study, Abstract)

[10] N.A.

[11] Jo Glass, Gruber Michael , Anit Nirenberg
Phase I/II Study of Carboplatin and Thalidomide in Recurrent Glioblastoma Multiforme
ASCO Proceedings, 1999 Annual Meeting, Abstract
No. 551 (Clinical Study)

[12] N.A.


Chapter 9 - Ethical Implications of the Clinical Trial System [1], [2], [3], [4], [5] N.A.
[6] Grant SC, Kris MG, Houghton AN, Chapman PB
Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guerin
Clin Cancer Res 1999 Jun;5(6):1319-23 (Clinical Study, Abstract)


Chapter 10 - Phase-III Trials: Gold Standard or Fool's Gold? [1], [2], [3], [4] N.A.
[5] Videtic GM, Gaspar LE, Zamorano L, Fontanesi J, Levin KJ, Kupsky WJ, Tekyi-Mensah S.
Use of the RTOG recursive partitioning analysis to validate the benefit of iodine-125 implants in the primary treatment of malignant gliomas.
Int J Radiat Oncol Biol Phys 1999 Oct 1;45(3):687-92 (Clinical Study, Abstract)

[6] N.A.

[7] Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB, Herman JG
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
N Engl J Med 2000 Nov 9;343(19):1350-4
(Clinical Study, Abstract)

[8] N.A.


Chapter 11 - Bastille Day for Cancer Patient
N.A.


Chapter 12 - Alternative Medicine [1], [2], [3], [4], [5], [6] N.A.

[7] Chlebowski RT, Lillington L, Nystrom JS, Sayre J
Late mortality and levamisole adjuvant therapy in colorectal cancer
Br J Cancer 1994 Jun;69(6):1094-7 (Clinical Study, Abstract)


[8], [9], [10] N.A.

[11] Filov VA, Gershanovich ML, Danova LA, Ivin BA
Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients
Invest New Drugs 1995;13(1):89-97 (Clinical Study, Abstract)

[12] N.A.

[13] Chlebowski RT, Bulcavage L, Grosvenor M, Oktay E, Block JB, Chlebowski JS, Ali I, Elashoff R
Hydrazine sulfate influence on nutritional status and survival in non-small-cell lung cancer
J Clin Oncol 1990 Jan;8(1):9-15 (Clinical Study, Abstract)

[14] Loprinzi CL, Kuross SA, O'Fallon JR, Gesme DH Jr, Gerstner JB, Rospond RM, Cobau CD, Goldberg RM.
Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer
J Clin Oncol 1994 Jun;12(6):1121-5 (Clinical Study, Abstract)


[15] Kosty MP, Fleishman SB, Herndon JE 2nd, Coughlin K, Kornblith AB, Scalzo A, Morris JC, Mortimer J, Green MR
Cisplatin, vinblastine, and hydrazine sulfate in advanced, non-small-cell lung cancer: a randomized placebo-controlled, double-blind phase III study of the Cancer and Leukemia Group B
J Clin Oncol 1994 Jun;12(6):1113-20 (Clinical Study, Abstract)


[16] Loprinzi CL, Goldberg RM, Su JQ, Mailliard JA, Kuross SA, Maksymiuk AW, Kugler JW, Jett JR, Ghosh C, Pfeifle DM, et al
Placebo-controlled trial of hydrazine sulfate in patients with newly diagnosed non-small-cell lung cancer
J Clin Oncol 1994 Jun;12(6):1126-9 (Clinical Study, Abstract)


[17] Kaegi E
Unconventional therapies for cancer: 3. Iscador. Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative
CMAJ 1998 May 5;158(9):1157-9 (Review Article, Reference | Full Text)


[18] N.A.

[19] Kuttan G, Menon LG, Antony S, Kuttan R
Anticarcinogenic and antimetastatic activity of Iscador
Anticancer Drugs 1997 Apr;8 Suppl 1:S15-6 (Animal Study, Abstract)

[20] Antony S, Kuttan R, Kuttan G
Effect of viscum album in the inhibition of lung metastasis in mice induced by B16F10 melanoma cells
J Exp Clin Cancer Res 1997 Jun;16(2):159-62 (Animal Study, Abstract)


[21] Kuttan G, Kuttan R
Reduction of leukopenia in mice by "viscum album" administration during radiation and chemotherapy
Tumori 1993 Feb 28;79(1):74-6 (Animal Study, Abstract)

[22] Lenartz D, Stoffel B, Menzel J, Beuth J.
Immunoprotective activity of the galactoside-specific lectin from mistletoe after tumor destructive therapy in glioma patients
Anticancer Res 1996 Nov-Dec;16(6B):3799-802 (Clinical Study, Abstract)

[23] Lenartz D, Dott U, Menzel J, Schierholz JM, Beuth J
Survival of glioma patients after complementary treatment with galactoside-specific lectin from mistletoe
Anticancer Res 2000 May-Jun;20(3B):2073-6 (Clinical Study, Abstract)

[24] Jagiello-Wojtowicz E, Kleinrok Z, Urbanska EM
Ukrain (NSC-631570) in experimental and clinical studies: a review
Drugs Exp Clin Res 1998;24(5-6):213-9 (Review Article, Abstract)

[25] Not Found

[26] Susak YM, Zemskov VS, Yaremchuk OY, Kravchenco OB, Yatsyk IM, Korsh OB
Comparison of chemotherapy and X-ray therapy with Ukrain monotherapy for colorectal cancer
Drugs Exp Clin Res 1996;22(3-5):115-22 (Clinical Study, Abstract)

[27] Zemskov VS, Procopchuk OL, Susak YM, Zemskov SV, Hodysh YY, Zemskova MV
Ukrain (NSC-631570) in the treatment of pancreas cancer
Drugs Exp Clin Res 2000;26(5-6):179-90 (Clinical Study, Abstract)

[28] Jaeckle KA, Mittelman A, Hill FH
Phase II trial of Serratia marcescens extract in recurrent malignant astrocytoma
J Clin Oncol 1990 Aug;8(8):1408-18 (Clinical Study, Abstract)

[29] Csatary LK, Eckhardt S, Bukosza I, Czegledi F, Fenyvesi C, Gergely P, Bodey B, Csatary CM
Attenuated veterinary virus vaccine for the treatment of cancer
Cancer Detect Prev 1993;17(6):619-27 (Clinical Study, Abstract)

[30] Batliwalla FM, Bateman BA, Serrano D, Murray D, Macphail S, Maino VC, Ansel JC, Gregersen PK, Armstrong CA
A 15-year follow-up of AJCC stage III malignant melanoma patients treated postsurgically with Newcastle disease virus (NDV) oncolysate and determination of alterations in the CD8 T cell repertoire
Mol Med 1998 Dec;4(12):783-94 (Clinical Study, Abstract)

[31] de la Taille A, Buttyan R, Hayek O, Bagiella E, Shabsigh A, Burchardt M, Burchardt T, Chopin DK, Katz AE
Herbal therapy PC-SPES: in vitro effects and evaluation of its efficacy in 69 patients with prostate cancer
J Urol 2000 Oct;164(4):1229-34 (Clinical Study, Abstract)

[32] N.A.

[33] Not Found

[34] Buckner JC, Malkin MG, Reed E, Cascino TL, Reid JM, Ames MM, Tong WP, Lim S, Figg WD
Phase II study of antineoplastons A10 (NSC 648539) and AS2-1 (NSC 620261) in patients with recurrent glioma
Mayo Clin Proc 1999 Feb;74(2):137-45 (Clinical Study, Abstract)


[35] Not Found

[36] N.A.


Chapter 13 - The Value of Supplements [1], [2] N.A.
[3] Cameron E, Pauling L
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer
Proc Natl Acad Sci U S A 1976 Oct;73(10):3685-9 (Clinical Study, Abstract)

[4] Cameron E, Pauling L
Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer
Proc Natl Acad Sci U S A 1978 Sep;75(9):4538-42 (Clinical Study, Reference)

[5] Creagan ET, Moertel CG, O'Fallon JR, Schutt AJ, O'Connell MJ, Rubin J, Frytak S
Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial
N Engl J Med 1979 Sep 27;301(13):687-90 (Clinical Study, Abstract)

[6] Not Found

[7], [8]  N.A.

[9] Not Found

[10] Prasad KN, Cole WC, Kumar B, Prasad KC
Scientific rationale for using high-dose multiple micronutrients as an adjunct to standard and experimental cancer therapies
J Am Coll Nutr 2001 Oct;20(5 Suppl):450S-463S (Review Article, Abstract | Full Text)

[11] Prasad KN, Kumar A, Kochupillai V, Cole WC
High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy
J Am Coll Nutr 1999 Feb;18(1):13-25 (Review Article, Abstract | Full Text)

[12] Salganik RI
The benefits and hazards of antioxidants: controlling apoptosis and other protective mechanisms in cancer patients and the human population
J Am Coll Nutr 2001 Oct;20(5 Suppl):464S-472SReview Article, Abstract | Full Text)

[13] Salganik RI, Albright CD, Rodgers J, Kim J, Zeisel SH, Sivashinskiy MS, Van Dyke TA
Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice

Carcinogenesis 2000 May;21(5):909-14 (Cell Culture Study, Abstract | Full Text)

[14] Sun AS, Ostadal O, Ryznar V, Dulik I, Dusek J, Vaclavik A, Yeh HC, Hsu C, Bruckner HW, Fasy TM
Phase I/II study of stage III and IV non-small cell lung cancer patients taking a specific dietary supplement
N
utr Cancer 1999;34(1):62-9
(Clinical Study, Abstract)

[15] Sun AS, Yeh HC, Wang LH, Huang YP, Maeda H, Pivazyan A, Hsu C, Lewis ER, Bruckner HW, Fasy TM
Pilot study of a specific dietary supplement in tumor-bearing mice and in stage IIIB and IV non-small cell lung cancer patients
Nutr Cancer 2001;39(1):85-95 (Animal Study | Clinical Study, Abstract)

[16] Kucuk O, Sarkar FH, Sakr W, Djuric Z, Pollak MN, Khachik F, Li YW, Banerjee M, Grignon D, Bertram JS, Crissman JD, Pontes EJ, Wood DP Jr
Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy
Cancer Epidemiol Biomarkers Prev 2001 Aug;10(8):861-8 (Clinical Study, Abstract | Full Text)

[17] N.A.

[18] Neri B, de Leonardis V, Gemelli MT, di Loro F, Mottola A, Ponchietti R, Raugei A, Cini G
Melatonin as biological response modifier in cancer patients
Anticancer Res 1998 Mar-Apr;18(2B):1329-32 (Clinical Study, Abstract)

[19] Lissoni P, Meregalli S, Nosetto L, Barni S, Tancini G, Fossati V, Maestroni G.
Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone
Oncology 1996 Jan-Feb;53(1):43-6 (
Clinical Study, Abstract)

[20] Lissoni P, Barni S, Ardizzoia A, Paolorossi F, Crispino S, Tancini G, Tisi E, Archili C, De Toma D, Pipino G, et al
Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first-line chemotherapy containing cisplatin
Oncology 1992;49(5):336-9 (Clinical Study, Abstract)

[21] Lissoni P, Brivio O, Brivio F, Barni S, Tancini G, Crippa D, Meregalli S
Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma
J Pineal Res 1996 Nov;21(4):239-42 (Clinical Study, Abstract)

[22] Barni S, Lissoni P, Cazzaniga M, Ardizzoia A, Meregalli S, Fossati V, Fumagalli L, Brivio F, Tancini G
A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates
Oncology 1995 May-Jun;52(3):243-5 (Clinical Study, Abstract)

[23] Lissoni P, Paolorossi F, Ardizzoia A, Barni S, Chilelli M, Mancuso M, Tancini G, Conti A, Maestroni GJ
A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state
J Pineal Res 1997 Aug;23(1):15-9 (Clinical Study, Abstract)

[24] N.A.

[25] Tsukagoshi S, Hashimoto Y, Fujii G, Kobayashi H, Nomoto K, Orita K
Krestin (PSK)
Cancer Treat Rev 1984 Jun;11(2):131-55 (Clinical Study | Review Article, Abstract)

[26] Kobayashi H, Matsunaga K, Oguchi Y
Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview
Cancer Epidemiol Biomarkers Prev 1995 Apr-May;4(3):275-81 (Review Article, Abstract)

[27] Chihara G
Recent progress in immunopharmacology and therapeutic effects of polysaccharides
Dev Biol Stand 1992;77:191-7 (Clinical Study | Review Article, Abstract)

[28] Hayakawa K, Mitsuhashi N, Saito Y, Takahashi M, Katano S, Shiojima K, Furuta M, Niibe H
Effect of krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer
Anticancer Res 1993 Sep-Oct;13(5C):1815-20 (Clinical Study, Abstract)

[29] Kaneko S, Abe H, Aida T, Tokuda K, Tsuru M, Kitaoka K, Sato M, Iwakuma T, Ueno K, Kashiwaba T
Evaluation of radiation immunochemotherapy in the treatment of malignant glioma. Combined use of ACNU, VCR and PS-K
Hokkaido Igaku Zasshi 1983 Nov;58(6):622-30 (Clinical Study, Abstract)

[30] N.A.

[31] Nanba H, Kubo K
Effect of Maitake D-fraction on cancer prevention
Ann N Y Acad Sci 1997 Dec 29;833:204-7 (
Animal Study, Reference)

[32] Arber N, DuBois RN
Nonsteroidal anti-inflammatory drugs and prevention of colorectal cancer
Curr Gastroenterol Rep 1999 Oct;1(5):441-8 (
Review Article, Abstract)

[33] Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM, Laposata M
gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial
Arthritis Rheum 1996 Nov;39(11):1808-17 (Clinical Study, Abstract)

[34] Jiang WG, Bryce RP, Horrobin DF
Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications
Crit Rev Oncol Hematol 1998 Apr;27(3):179-209 (Review Article, Reference)

[35] N.A.

[36] Kenny FS, Pinder SE, Ellis IO, Gee JM, Nicholson RI, Bryce RP, Robertson JF
Gamma linolenic acid with tamoxifen as primary therapy in breast cancer
Int J Cancer 2000 Mar 1;85(5):643-8 (Clinical Study, Abstract)

[37] Fearon KC, Falconer JS, Ross JA, Carter DC, Hunter JO, Reynolds PD, Tuffnell Q
An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate
Anticancer Res 1996 Mar-Apr;16(2):867-74 (Clinical Study, Abstract)

[38] Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F
Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial
Cancer 1998 Jan 15;82(2):395-402 (Clinical Study, Abstract)

[39] Ip C
Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals
Am J Clin Nutr 1997 Dec;66(6 Suppl):1523S-1529S (Animal Study, Abstract)

[40] Not Found

[41]  Penar PL, Khoshyomn S, Bhushan A, Tritton TR
Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain
Neurosurgery 1997 Jan;40(1):141-51
(Cell Culture Study, Abstract)

[42] Li D, Yee JA, McGuire MH, Murphy PA, Yan L
Soybean isoflavones reduce experimental metastasis in mice

J Nutr 1999 May;129(5):1075-8 (Animal Study, Abstract | Full Text)

[43] Baltuch GH, Yong VW
Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathway
Brain Res 1996 Feb 26;710(1-2):143-9 (Cell Culture Study, Abstract)

[44] Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK
Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice
J Nutr 1999 Sep;129(9):1628-35 (Animal Study, Abstract | Full Text)

[45] Clark LC, Combs GF Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL Jr, Park HK, Sanders BB Jr, Smith CL, Taylor JR
Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group
JAMA 1996 Dec 25;276(24):1957-63 (Clinical Study, Abstract)

[46] Sundaram N, Pahwa AK, Ard MD, Lin N, Perkins E, Bowles AP Jr
Selenium causes growth inhibition and apoptosis in human brain tumor cell lines
J Neurooncol 2000;46(2):125-33 (Cell Culture Study, Abstract)

[47] Kuroda Y, Hara Y
Antimutagenic and anticarcinogenic activity of tea polyphenols
Mutat Res 1999 Jan;436(1):69-97 (Review Article, Abstract)

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[23] Pietro Riva, Giancarlo Franceschi, Massimo Frattarelli, Nada Riva, Graziano Guiducci, Anna Maria Cremonini, Graziano Giuliani, Michela Casi, Rossella Gentile, Annti A. Jekunen, Kalevi J. A. Kairemo
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