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SV40-positive
brain tumor in scientist with risk of laboratory exposure to the virus
Arrington AS, Moore MS, Butel JS
Department of Molecular Virology and Microbiology, Baylor College
of Medicine, Houston, TX 77030, USA.
Simian virus 40 (SV40) is a DNA tumor virus known to induce cancers in
laboratory animals.
There are numerous reports of the detection of SV40 DNA and/or proteins in human
malignancies of the same types as those induced by SV40 in animals, including
brain cancers.
However, known exposure to the virus has not yet been linked directly to cancer
development in a specific individual.
Here we describe the detection of SV40 sequences in the meningioma of a
laboratory researcher who had a probable direct exposure to SV40 and
subsequently developed a tumor positive for viral DNA sequences
indistinguishable from those of the laboratory source.
This case suggests a link between viral exposure and tumor development.
Oncogene advance online publication, 15 December 2003;
doi:10.1038/sj.onc.1207341
PMID: 14676832 [PubMed - as supplied by publisher]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14676832&dopt=Abstract
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