Carboplatin
and teniposide as third-line chemotherapy in patients with recurrent
oligodendroglioma or oligoastrocytoma: a phase II study
A. A. Brandes, U. Basso, F. Vastola, A. Tosoni, L.
M. Pasetto, A. Jirillo, S. Lonardi, M. K. Paris, H. Koussis, S. Monfardini and
M. Ermani
Department
of Medical Oncology and Neurological Sciences of Azienda Ospedale-Università,
Padua, Italy.
Received 21 April 2003; revised 8 July 2003; accepted 12 August 2003.
Background. This
study was a phase II study of third-line chemotherapy with carboplatin
plus teniposide in patients with recurrent oligodendroglioma.
Patients and methods.
Patients with
oligodendroglioma progressive or recurrent after surgery,
radiotherapy and chemotherapy with PCV (lomustine/procarbazine/vincristine)
and temozolomide were treated with 350 mg/m2 carboplatin on
day 1, and 50 mg/m2 teniposide on days 1–3, every 4 weeks.
Results. Response
and toxicity were evaluated in all 23 patients enrolled in the
study.
Two had partial response [8.6%; 95% confidence interval (CI) 1.8% to
28.6%] and 12 stable disease (52.17%; 95% CI 30% to 73%).
Median time to progression was 19 weeks (95% CI 11.4–35.0), and
34.8% of the patients (95% CI 20.0% to 61.0%) had progression-free
survival at 6 months.
Median survival time was 60.7 weeks (95% CI 39.8 to not achieved) and
51% of the patients (95% CI 33.5% to 79.7%) were alive at 12 months.
A total of 103 cycles were administered (on average 4.4 per patient;
range 1–9).
Toxicity was mild and mainly hematological, with grade 4 neutropenia
and grade 4 thrombocytopenia in two (8.6%) and three patients (13%),
respectively.
Conclusions. Although
the response rate of combined carboplatin and teniposide chemotherapy
in heavily pretreated oligodendroglial tumors is moderate, the
toxicity is manageable, and delay of progression in responders or
stable patients may still confer a relevant clinical benefit.
Key words: carboplatin,
chemotherapy, oligodendroglioma, salvage therapy, teniposide
© 2003
European
Society for Medical Oncology
Source: http://annonc.oupjournals.org/cgi/content/abstract/14/12/1727?etoc |
