From: Subject: Cannabinoids: potential anticancer agents : Abstract : Nature Reviews Cancer Date: Sat, 3 May 2008 14:31:40 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C8AD2A.66EBF2F0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C8AD2A.66EBF2F0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nrc/journal/v3/n10/abs/nrc1188.html Cannabinoids: = potential anticancer agents : Abstract : Nature Reviews Cancer

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Nature Reviews Cancer = 3, 745-755 = (October 2003) | = doi:10.1038/nrc1188

Cannabinoids: potential anticancer agents

Manuel Guzm=E1n1 =20 Ab= out the=20 author

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Abstract

Cannabinoids =97 the active components of Cannabis=20 sativa and their derivatives =97 exert palliative effects in = cancer=20 patients by preventing nausea, vomiting and pain and by stimulating = appetite. In=20 addition, these compounds have been shown to inhibit the growth of = tumour cells=20 in culture and animal models by modulating key cell-signalling pathways. = Cannabinoids are usually well tolerated, and do not produce the = generalized=20 toxic effects of conventional chemotherapies. So, could cannabinoids be = used to=20 develop new anticancer therapies?

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Author affiliations

  1. Department of Biochemistry and Molecular Biology I, School = of=20 Biology, Complutense University, 28040 Madrid, Spain. =
    Email: mgp@bbm1.ucm.es
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RESEARCH
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Nature Reviews Cancer

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url(/common/images/icons/rss.gif) = no-repeat left center } A.rss:hover { BACKGROUND: url(/common/images/icons/rss.gif) no-repeat left center } #extranav A.rss { PADDING-LEFT: 22px; BACKGROUND: url(/common/images/icons/newsfeeds.gif) = no-repeat left center; PADDING-BOTTOM: 2px; PADDING-TOP: 1px } #extranav A.receive { PADDING-LEFT: 22px; BACKGROUND: url(/common/images/icons/newsfeeds.gif) = no-repeat left center; PADDING-BOTTOM: 2px; PADDING-TOP: 1px } #content SPAN.free { COLOR: #c03; TEXT-DECORATION: none } .dev-error { FONT-WEIGHT: bold; FONT-SIZE: 80%; BACKGROUND: #f00; COLOR: #fff } .b { FONT-WEIGHT: bold } .i { FONT-STYLE: italic } .latin { FONT-STYLE: italic } H1.page-header { FONT-WEIGHT: bold; FONT-SIZE: 140%; PADDING-BOTTOM: 4px; MARGIN: 15px = 0px 10px; BORDER-BOTTOM: #eaeaea 1px solid } SPAN.page-header-spacer { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140%; VISIBILITY: hidden; = PADDING-BOTTOM: 4px; MARGIN: 15px 0px 0px } SPAN.booktitle { FONT-STYLE: italic } SPAN.journalname { FONT-STYLE: italic } SPAN.journalnumber { FONT-WEIGHT: bold } SPAN.tm { VERTICAL-ALIGN: super } LEGEND { COLOR: #000 } * HTML #breadcrumb DIV { MARGIN-TOP: 0px; PADDING-LEFT: 5px; PADDING-TOP: 1px } #breadcrumb DIV { CLEAR: left; MARGIN-TOP: 0px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 10px; PADDING-TOP: 1px } #breadcrumb DIV A:link { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:visited { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:hover { COLOR: #000; TEXT-DECORATION: underline } #breadcrumb SPAN.divider { FONT-SIZE: 70%; COLOR: #000 } #breadcrumb SPAN.thisitem { FONT-SIZE: 70%; COLOR: #000 } #login-inpage { MARGIN: 0px; COLOR: #000; BACKGROUND-COLOR: #eaeaea } #login-inpage A { FONT-SIZE: 70% } #login-inpage DIV.userpassbox { FLOAT: left; WIDTH: 8em } #login-inpage .passdetails { CLEAR: left } #login-inpage INPUT.text { FONT-SIZE: 80%; MARGIN: 0px; WIDTH: 9em; COLOR: #000 } #login-inpage LABEL { FONT-SIZE: 70% } #login-inpage INPUT.button { MARGIN-TOP: 5px } #login-inpage #savepass-inpage { MARGIN-BOTTOM: -2px } #login-inpage DIV.error { PADDING-LEFT: 20px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/login_error.gif) no-repeat 0px 4px; MARGIN-BOTTOM: = 5px; COLOR: #c30 } #login-inpage DIV.error SPAN { FONT-WEIGHT: bold } #head-er HR { DISPLAY: none } #head-er .header-nonad-wrapper { PADDING-BOTTOM: 15px; BORDER-BOTTOM: #fff 1px solid } #head-er .accessibility-login-wrap { FLOAT: left; WIDTH: 100%; BORDER-BOTTOM: #000 1px solid; = BACKGROUND-COLOR: #eaeaea } #head-er .accessibility-login { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 4px; TEXT-ALIGN: right } #head-er .accessibility-login A.nature-link { FLOAT: left; FONT: bold 160%/80% Garamond, serif; WIDTH: 4.9em; COLOR: = #b1062e; MARGIN-RIGHT: 20px; TEXT-ALIGN: left; TEXT-DECORATION: none } * HTML #head-er .accessibility-login A.nature-link:hover { BACKGROUND: none transparent scroll repeat 0% 0% } #head-er .accessibility-login A.nature-link:hover { BACKGROUND: = url(/common/includes/header/images/nature.com.underline.gif) no-repeat = left bottom } #head-er .accessibility-login IMG.nature-logo { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 1px 20px 0px 0px; WIDTH: 82px! = important; HEIGHT: 11px; BORDER-RIGHT-WIDTH: 0px } #head-er .accessibility-login .jumplinks { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 45%; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } #head-er .accessibility-login .jumplinks LI { DISPLAY: inline; PADDING-LEFT: 15px } #head-er .accessibility-login .jumplinks LI.first { PADDING-LEFT: 0px } #head-er .accessibility-login .jumplinks A { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/b1062e/arrow_down.gif) no-repeat left center; = COLOR: #000; TEXT-DECORATION: none } #head-er .accessibility-login .jumplinks A:hover { TEXT-DECORATION: underline } #head-er DIV.logon { =09 } #head-er .logon .onlyformacie { FONT-SIZE: 3px } #head-er .logon .onlyformacie { DISPLAY: none } #head-er .logon A.login { PADDING-RIGHT: 15px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logon.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon A.login:hover { BACKGROUND: url(/common/includes/header/images/logon_over.gif) = no-repeat right center; TEXT-DECORATION: underline } #head-er .logon A.login:active { BACKGROUND: url(/common/includes/header/images/logon.gif) no-repeat = right center } #head-er .logon A.logoff { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logoff.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon P { MARGIN: 0px } #head-er .logon .user { FONT-WEIGHT: bold } #head-er .logon .inst { FONT-WEIGHT: bold } #head-er .image-user-services-wrap { FLOAT: left; WIDTH: 100%; BACKGROUND-COLOR: #d6335c } #head-er .image-user-services { BORDER-BOTTOM: transparent 1px solid } * HTML #head-er .image-user-services { BORDER-BOTTOM-WIDTH: 0px } #head-er .image-user-services IMG.journal-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; WIDTH: 344px; HEIGHT: 74px; = BORDER-RIGHT-WIDTH: 0px } #head-er .user-services { FLOAT: right } #head-er .div1.user-services { WIDTH: 12.35em! important } #head-er .div2.user-services { WIDTH: 8.7em! important } #head-er .user-services UL { BORDER-RIGHT: #fff 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: #fff 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 22px 0px 21px; = BORDER-LEFT: #fff 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 0px = solid; LIST-STYLE-TYPE: none; TEXT-ALIGN: right } #head-er .user-services UL.list1 { BORDER-RIGHT: #fff 1px solid } #head-er .user-services LI { BORDER-BOTTOM: #fff 1px solid } #head-er .user-services A { PADDING-RIGHT: 13px; DISPLAY: block; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) #767474 no-repeat right = center; PADDING-BOTTOM: 1px; TEXT-TRANSFORM: uppercase; COLOR: #fff; = PADDING-TOP: 1px; TEXT-DECORATION: none } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .publications-search-wrap { BACKGROUND: #000 } * HTML #head-er .publications-search { PADDING-BOTTOM: 3px; PADDING-TOP: 3px } #head-er .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 4px; = PADDING-TOP: 4px } * HTML #head-er .publications { MARGIN: 6px 0px 0px } #head-er .publications { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4px 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #head-er .publications LI { DISPLAY: inline; MARGIN-LEFT: 10px } #head-er .publications LI.first { MARGIN-LEFT: 0px } #head-er .publications A { PADDING-RIGHT: 15px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .publications A:hover { TEXT-DECORATION: underline } #head-er .search { TEXT-ALIGN: right } #head-er .search FORM { DISPLAY: inline; MARGIN: 0px } #head-er .search FORM A { PADDING-RIGHT: 14px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .search FORM A:hover { TEXT-DECORATION: underline } #head-er #searchtext { WIDTH: 10em } #head-er .publications-search LABEL { TEXT-TRANSFORM: uppercase; COLOR: #fff } #head-er INPUT { FONT-SIZE: 100% } #head-er SELECT { FONT-SIZE: 100% } #head-er .publications-search INPUT.button { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px } #head-er .accessibility-login { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .image-user-services { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .publications-search { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } .header-leaderboard-wrap { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: = url(/common/includes/header/images/bg_leaderboard.gif) no-repeat 50% = 0px; OVERFLOW: hidden } .header-leaderboard { MAX-HEIGHT: 105px; TEXT-ALIGN: center } * HTML .header-leaderboard IMG { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard ilayer { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard IFRAME { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard EMBED { BORDER-BOTTOM-WIDTH: 1px } .header-leaderboard IMG { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard ilayer { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard IFRAME { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard EMBED { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard TABLE { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MAX-WIDTH: 728px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: auto; WIDTH: 100%; MARGIN-RIGHT: auto; PADDING-TOP: 0px; = BORDER-BOTTOM: #fff 1px solid; BORDER-RIGHT-WIDTH: 0px } * HTML .header-leaderboard TABLE IMG { HEIGHT: auto } #constrain { MARGIN-TOP: 14px } #global-subject-areas { BORDER-RIGHT: #ebebeb 1px solid; BORDER-TOP: #ebebeb 1px solid; = BACKGROUND: #ebebeb; MARGIN: 0px 0px 20px; BORDER-LEFT: #ebebeb 1px = solid; BORDER-BOTTOM: #ebebeb 1px solid } #global-subject-areas ABBR { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px; TEXT-DECORATION: none } #global-subject-areas A:link { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:visited { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:hover { TEXT-DECORATION: underline } #global-subject-areas H2 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #global-subject-areas UL UL { FONT-SIZE: 100% } #global-subject-areas UL LI { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = LINE-HEIGHT: 150%; PADDING-TOP: 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL LI LI { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #global-subject-areas UL LI H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H5 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H6 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav { DISPLAY: block; MARGIN-BOTTOM: 20px } MAP.journal-nav UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } MAP.journal-nav UL LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } MAP.journal-nav UL LI.grouped { BORDER-BOTTOM: #eaeaea 1px solid } * HTML MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } * HTML MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:hover { COLOR: #fff; BACKGROUND-COLOR: #c00; TEXT-DECORATION: none } MAP.journal-nav UL LI A.on { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.on:visited { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.submission { PADDING-LEFT: 20px! important; BACKGROUND: = url(/common/images/online_submissions.gif) no-repeat left center } MAP.journal-nav UL LI UL.subnav { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } MAP.journal-nav UL LI UL.subnav LI { BACKGROUND: url(/common/images/nav_dots2.gif) #fafafa no-repeat 11px = 5px; BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px } MAP.journal-nav UL LI UL.subnav LI.on { BACKGROUND: url(/common/images/nav_dots1.gif) 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