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Alternative
lengthening of telomeres and survival in patients with glioblastoma multiforme
Hakin-Smith
V, Jellinek DA, Levy D, Carroll T, Teo M, Timperley WR, McKay MJ, Reddel RR,
Royds JA
Institute
for Cancer Studies, Medical School, Sheffield, UK
Despite
advances in the molecular pathogenesis of glioblastoma multiforme, no reliable
prognostic markers have been identified.
We analysed telomerase activity and telomere lengths in glioblastoma multiformes
from 77 patients.
19 patients (25%) had tumours with the alternative-lengthening-of-telomere (ALT)
phenotype.
Median survival for patients with this phenotype was 542 days (95% CI 114-970)
compared with 247 days (224-270) for glioblastoma multiformes with normal
telomeres (p=0.0003).
Cox's regression analysis showed that this association is independent of age.
In patients with non-ALT tumours, telomerase activity did not affect survival
(median 287 [199-375] vs 236 [230-242] days, p=0.275).
We conclude that ALT is a prognostic indicator for patients with glioblastoma
multiforme.
PMID:
12642053 [PubMed - in process]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12642053&dopt=Abstract
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