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Cyclo-oxygenase
II inhibitors in the treatment of neoplastic fever
Kathula
SK, Shah K, Polenakovik H, Koduri J
Department
of Medicine, Wright State University, Dayton, Ohio, USA.
satish@kathula.com
Neoplastic
fever is relatively common in cancer patients.
Naproxen is one of the most commonly used non-steroidal anti-inflammatory drugs
for the treatment of neoplastic fever.
Naproxen is associated with platelet dysfunction and gastrointestinal side
effects.
We substituted rofecoxib, a cyclooxygenase-II inhibitor, for naproxen in
patients with a previous history of, or a newly diagnosed, neoplastic fever in
whom naproxen was relatively contraindicated.
In all patients the fever resolved completely without any side effects.
PMID:
12673465 [PubMed - in process]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12673465&dopt=Abstract
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