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The
Early Successful Treatment of Glioblastoma Patients with Modified boron Neutron
Capture Therapy
Shinji
Kawabata¹,
Shin-Ichi
Miyatake¹,
Yoshinaga
Kajimoto¹,
Yuzo
Kuroda¹,
Toshihiko
Kuroiwa¹,
Yoshio
Imahori², Mitsunori
Kirihata³,
Yoshinori
Sakuraiº,
Tohru
Kobayashiº, Koji
Onoº
¹Department
of Neurosurgery, Osaka Medical College, Osaka;
²Department
of Neurosurgery, Kyoto Prefectural University of Medicine, Kyoto; ³Department
of Agriculture, Osaka Prefectural University; ºRadiation Oncology Research Laboratory, Kyoto University, Research Reactor
Institute, Osaka, Japan
We very
effectively treated two patients with recurrent glioblastoma with modified boron
neutron capture therapy (BNCT).
In this paper, we describe the effectiveness of this treatment, and discuss the
ways in which we modified the treatment.
A 61-year-old man had a first operation for a right temporal glioblastoma,
followed by full-dose chemo-radiotherapy.
One year after the operation a partial removal was performed for the recurrent
tumor at the same site.
Fifty days after the second surgery, the patient received BNCT.
We used an epithermal neutron beam as the neutron source, and used both sodium
borocapate and boronophenylalanine as boron compounds with the craniotomy.
Forty-eight hours after the BNCT, the follow-up MRI was applied to estimate the
early effect of this treatment, which showed a 70% reduction in the contrast
enhanced lesion, compared with the pretreatment MRI.
In addition, the lesion/normal brain ratio of thallium-SPECT had improved
markedly.
No serial sequelae appeared after this treatment, and the patient remains
healthy 6 months after the treatment.
A
29-year-old young lady had a right temporal brain tumor, which was partially
resected and followed by stereotactic radiosurgery for the residual mass.
Seven months after the radiosurgery, a second operation was performed, which
revealed the glioblastoma as diagnosis.
We applied BNCT uneventfully for this patient with epithermal beam and two kinds
of boron compounds as described above.
For the treatment of the patient irradiation was applied without craniotomy with
marked reduction of tumor volume immediately after the treatment.
Keywords:
BNCT, BPA, BSH, epithermal neutron, glioblastoma
Copyright
© 2003 Kluwer
Academic Publishers. All
rights reserved
Source: http://ipsapp009.kluweronline.com/content/getfile/5042/104/9/abstract.htm |
