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The
prognostic value of cognitive functioning in the survival of patients with
high-grade glioma
Klein M, Postma TJ, Taphoorn MJ, Aaronson NK, Vandertop WP, Muller M, Van Der
Ploeg HM, Heimans JJ
Departments of Medical Psychology (Drs. Klein and van der Ploeg),
Neurology (Drs. Postma and Heimans), and Neurosurgery (Dr. Vandertop), VU
University Medical Center, Amsterdam.
The authors studied cognitive functioning as a potential predictor of survival
in 68 newly diagnosed patients with high-grade glioma.
In a combined Cox proportional hazards model, the influence of tumor, treatment,
and patient characteristics, including cognitive functioning, was studied.
Older age and higher tumor grade were associated with poorer survival.
Although cognitive impairment was not found to be an independent prognostic
factor for the entire sample, it was associated with significantly poorer
survival among older patients with World Health Organization grade IV
gliomas.
Assessment of cognitive functioning in these patients may improve clinical
decision making and thus quality of treatment.
PMID: 14694052 [PubMed - in process]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14694052&dopt=Abstract
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