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Markers
of cellular proliferation are expressed in cortical tubers
Lee A, Maldonado M, Baybis M, Walsh CA, Scheithauer B, Yeung R, Parent J,
Weiner HL, Crino PB
Department of Neurology, University of Pennsylvania Medical
Center, Philadelphia, PA 19104, USA.
p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD,
and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell
astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the
developmental phenotype and lineage of giant cells (CGs) in these lesions.
Many GCs exhibited HuD and NeuN immunolabeling suggesting a differentiated
neural phenotype.
Giant cells in tubers, SEGAs and subependymal nodules in the Eker rat model of
TSC expressed CRMP4 and DCX.
Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may
share a common cellular lineage.
Tubers may contain a subpopulation of newly generated cells.
PMID: 12731003 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12731003&dopt=Abstract
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