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Continuous
growth of mean tumor diameter in a subset of grade II gliomas
Mandonnet
E, Delattre JY, Tanguy ML, Swanson KR, Carpentier AF, Duffau H, Cornu
P, Van Effenterre R, Alvord EC Jr, Capelle L
Federation
de Neurologie Mazarin and INSERM U495, and Service de Neurochirurgie,
Hopital de la Salpetriere (AP-HP), Paris.
Serial
magnetic resonance images of 27 patients with untreated World Health
Organization grade II oligodendrogliomas or mixed gliomas were
reviewed retrospectively to study the kinetics of tumor growth before
anaplastic transformation.
Analysis
of the mean tumor diameters over time showed constant growth.
Linear
regression, using a mixed model, found an average slope of 4.1mm per
year (95% confidence interval, 3.8-4.4mm/year).
Untreated
low-grade oligodendrogliomas or mixed gliomas grow continuously during
their premalignant phase, and their pattern of growth can be predicted
within a relatively narrow range.
These
findings could be of interest to optimize patients management and
follow-up.
PMID: 12666121 [PubMed - indexed for MEDLINE]
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