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Predicting
intellectual outcome among children treated with 35-40 Gy craniospinal
irradiation for medulloblastoma
Palmer SL, Gajjar A, Reddick WE, Glass JO, Kun LE, Wu S, Xiong X, Mulhern RK
Division of Behavioral Medicine, St. Jude Children's Research
Hospital, Memphis, TN 38105-2794, USA. shawna.palmer@stjude.org
Fifty children diagnosed with medulloblastoma completed 188 psychological
evaluations using the Wechsler Intelligence Scales for Children (D. Wechsler,
1974, 1991) over a 7-year study period following 35-40 Gy postoperative
craniospinal irradiation.
Random coefficient models were used to predict the trend in the children's
intellectual performance as a function of time since diagnosis, with both
patient and treatment variables as parameters of this function.
A quadratic model demonstrated a delay prior to decline in performance for older
patients, whereas the younger patients showed an immediate loss of performance
with a plateau at approximately 6 years postdiagnosis.
A steeper decline was found for those with higher baseline performance.
Clinicians may use the proposed predictive model to identify those patients who
are at risk of significant intellectual decline.
PMID: 14599268 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14599268
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