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Combined
positron emission tomography and magnetic resonance imaging for the planning of
stereotactic brain biopsies in children: experience in 9 cases
Pirotte
B, Goldman S, Salzberg S, Wikler D, David P, Vandesteene A, Van Bogaert P,
Salmon I, Brotchi J, Levivier M
Department
of Neurosurgery, Erasme Hospital, Universite Libre de Bruxelles, Brussels,
Belgium.
bpirotte@ulb.ac.be
Because
brain tumors can be histologically heterogeneous, stereotactic brain biopsies (SBB)
may lead to inaccurate diagnosis or grading.
Positron emission tomography (PET) has been used in pediatric neuro-oncology to
help in the understanding and management of brain neoplasms.
We combined PET and magnetic resonance (MR) imaging in the planning of SBB in 9
children (5 males and 4 females, aged 2-14 years) with infiltrative, ill-defined
brain lesions.
Tracers used for PET were (18)F-2-fluoro-2-deoxy-D-glucose in 4 cases,
(11)C-methionine in 2 cases and both tracers in 3 cases.
Biopsy targets were selected in hypermetabolic areas.
PET-guided SBB provided accurate histological diagnosis in all patients and
allowed a reduction of the number of trajectories in lesions located in
functional areas. It also helped in better understanding and management of
complex cases.
This preliminary series suggests that combining PET and MR imaging in the
planning of SBB in children
(1) improves the diagnostic yield of SBB in infiltrative, ill-defined brain
lesions,
(2) makes it possible to reduce the sampling in high-risk/functional areas and
(3) improves the quality of therapeutic management of pediatric brain tumors.
Copyright 2003 S. Karger AG, Basel
PMID:
12601239 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12601239&dopt=Abstract
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