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Perfusion
MRI in the evaluation of the relationship between tumour growth, necrosis and
angiogenesis in glioblastomas and grade 1 meningiomas
Principi M, Italiani M, Guiducci A, Aprile I, Muti M,
Giulianelli G, Ottaviano P
Operative
Unit of Neuroradiology, Azienda Ospedaliera Santa Maria, Via T. Di Joannuccio 1,
05100, Terni, Italy.
tompamas@tiscalinet.it
Angiogenesis
is a common characteristic of tumours, and it is reasonable to assume that it
has an influence on tumour growth, depending on the grade of malignancy.
We therefore studied angiogenesis in 25 patients: 14 with glioblastoma
multiforme and 11 with grade I meningioma.
Our aim was to assess how angiogenesis conditions growth and necrosis.
The patients underwent MRI with standard and perfusion sequences.
We calculated the volume of each tumour; for the glioblastomas the solid portion
was taken as the difference between the overall volume and the volume of any
necrotic portion.
In the glioblastomas, we found an inverse relationship between blood volume and
the size of the tumour, whereas in the meningiomas there was of a direct
relationship.
These correlations confirm in vivo the knowledge about necrosis in glioblastomas
and its relationship to their inadequate vascular network.
On the contrary, grade 1 meningiomas show an equilibrium between their
microcirculation and the cellular component.
PMID:
12687302 [PubMed - in process]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12687302&dopt=Abstract
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