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Growth
factor analysis of low-grade glioma CSF: PDGF and VEGF are not
detectable
Ribom
D, Larsson A, Pietras K, Smits A
Department
of Neuroscience, Neurology, University Hospital, University of
Uppsala, SE-751 85 Uppsala, Sweden.
Platelet-derived growth factor (PDGF), vascular endothelial growth
factor (VEGF) and fibroblast growth factor 2 (FGF-2) are involved in
the development of grade 2 gliomas.
The
aim of the present study was to determine the presence of these growth
factors in the cerebrospinal fluid (CSF) and to assess their
usefulness as biological markers.
CSF
was collected from 7 adult patients with newly diagnosed
supratentorial low-grade gliomas by lumbar puncture and was analysed
together with matched serum samples using radioreceptor and
enzyme-linked immunosorbant assays.
Neither
PDGF nor VEGF were detected in the CSF, and FGF-2 was measurable at
extremely low concentrations in only 2 of 7 patients.
Serum
levels were within normal limits.
We
conclude that these growth factors are not released into the CSF in
any significant amounts and are therefore not suitable as biological
markers in grade 2 gliomas.
PMID: 12827542 [PubMed - indexed for MEDLINE]
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