5, Number 3, July 2003, Page: 153 -- 160 (Clinical Study)
Prospective clinical trials of intracranial low-grade glioma in adults and children
Edward G. Shaw, Jeffrey H. Wisoff
Over the last decade, the results of 5 prospective clinical trials of
intracranial low-grade glioma (LGG) have been published, 4 in adults with
supratentorial LGG and 1 in children with infra- and supratentorial LGG.
European Organization for Research and Treatment of Cancer study 22845
randomized 311 adults to postoperative observation or radiation therapy
European Organization for Research and Treatment of Cancer study 22844
randomized 379 adults to low-dose (45 Gy) versus high-dose (59.4 Gy) RT.
A Southwest Oncology Group study randomized 54 adults with incompletely
resected LGG to RT alone or RT plus CCNU (lomustine) chemotherapy.
An intergroup study of the Children's Cancer Group and Pediatric Oncology
Group enrolled 660 pediatric patients with management based on the extent of
surgical resection: Children who underwent gross total tumor resection were
observed postoperatively, whereas those who had subtotal resection or biopsy
were either observed or administered RT at the discretion of their
The data from these 5 studies indicate that for intracranial LGG in
adults, postoperative RT is associated with improved 5-year PFS but not OS rates
compared to postoperative observation.
© 2003 Duke University PressSource: http://ninetta.ingentaselect.com/vl=1147881/cl=11/nw=1/rpsv/cgi-bin/linker?ini=dup_no&reqidx=/cw/dup/15228517/v5n3/s2/p153