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ABO
blood group is a risk factor for venous thromboembolism in patients with
malignant gliomas
M. B. Streiff, E. G. Weir, T. S. Kickler, M. Htut,
S. A. Grossman
Johns Hopkins Medical Institutions, Baltimore, MD
Venous thromboembolism (VTE) is a common cause of
morbidity and mortality among patients with malignant gliomas.
The etiology of VTE in these patients remains incompletely understood.
To identify risk factors for VTE among glioma patients, we conducted a
retrospective chart review of 107 randomly-selected adult patients with newly
diagnosed gliomas who had their primary therapy at our institution from 1991
through 2000.
Objective documentation of VTE by radiological testing or autopsy was required.
The association between laboratory and clinical characteristics and VTE was
assessed using parametric and nonparametric tests for continuous and categorical
data, as appropriate.
Twenty-seven of 107 patients (25%) were diagnosed with VTE during their clinical
course.
No association was noted between VTE and patient age, gender, race, the presence
of limb paresis, obesity, tumor size, tumor grade, duration of operative
procedure, the administration of chemotherapy, median hemoglobin, prothrombin
time, or activated partial thromboplastin time.
In contrast, a significant association between VTE and ABO blood group was
detected.
In this series of patients, AB blood group was 7 fold more common and blood
group O was 2 fold less common in VTE+ patients (Χ2 test for trend p=0.016).
Factor VIII activity is known to be significantly higher among subjects with AB
blood group compared with blood group O (McCallum et al. Thromb Haemostas 1983),
and elevated factor VIII levels are known to increase the risk of VTE by 4-6
fold. (Kyrle et
al. NEJM 2000)
These data suggest that ABO blood group may play a major role as a risk factor
for VTE in patients with malignant gliomas.
Prospective studies to confirm this association are warranted.
ABO
blood group frequencies and venous thromboembolism
(VTE) in glioma patients
|
Blood
Group
|
VTE
+ patients
|
VTE
- patients
|
US
population*
|
|
O
|
21%
|
38%
|
45%
|
|
A
|
50%
|
43%
|
40%
|
|
B
|
8%
|
16%
|
11%
|
|
AB
|
21%
|
3%
|
4%
|
|
*US
population ABO blood group frequencies derived from Wintrobe's Clinical
Hematology edited by Lee G.R. et al. 9th edition 1993 p.618.
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© Copyright 2003
American Society of Clinical Oncology All rights
reserved worldwide
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