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Clinical
Trials of Adenoviruses in Brain Tumors: A Review of Ad-p53 and Oncolytic
Adenoviruses
Giacomo
G. Vecil, Frederick F. Lang
Department
of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston,
TX, USA
Adenoviruses
have been critical in the development of the molecular approaches to brain
tumors.
They have been engineered to function as vectors for delivering therapeutic
genes in gene therapy strategies, and as direct cytotoxic agents in oncolytic
viral therapies.
This review outlines the uses of adenoviruses in brain tumor therapy by
examining clinical trials of adenovirus-mediated p53 gene therapy and by
reviewing the application of two conditionally replicative adenoviruses (CRAds)
ONYX-015 and Delta 24 in brain tumors.
The potential clinical use of CRAds that deliver trangenes, particularly p53, is
also discussed.
Keywords: adenovirus, Delta-24, , gene therapy,
glioblastoma, ONYX-015, p53
Copyright
© 2003 Kluwer
Academic Publishers. All
rights reserved
Source: http://ipsapp009.kluweronline.com/content/getfile/5042/105/7/abstract.htm
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