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Clinical
Gene Therapy for Brain Tumors. Liposomal Delivery of Anticancer Molecule to
Glioma
Jun
Yoshida¹,
Masaaki Mizuno²
¹Department
of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. ²Department
of Molecular Neurosurgery, Nagoya University Graduate School of Medicine,
Nagoya, Japan
Liposomes
are one of the most promising delivery systems for genes, proteins, and other
biological molecules and they are expected to become a new therapeutic tool for
the treatment of brain tumors, especially malignant gliomas.
Until now, transfer of anticancer molecules using liposomes has been studied by
a lot of investigators and it has been found to induce regression of
experimental gliomas, resulting in establishing some original and effective
therapies.
Gene therapy using cationic liposomes is also one of them.
Here we introduce the advanced medicine for brain tumors using liposomes
containing some anticancer molecules (for example, gene, antibody, antisense, or
magnetite), based on our basic and clinical research.
Keywords:
brain tumor, gene therapy, interferon, liposome
Copyright
© 2003 Kluwer
Academic Publishers. All
rights reserved
Source: http://ipsapp009.kluweronline.com/content/getfile/5042/105/9/abstract.htm
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