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Transmission of glioblastoma multiforme
following bilateral lung transplantation from an affected donor: Case study and
review of the literature
Mary Y. Armanios, Stuart A. Grossman, Stephen C. Yang, Barbara White, Arie
Perry, Peter C. Burger, Jonathan B. Orens
Department of Oncology
(M.Y.A., S.A.G.); Department of Surgery, Division of Thoracic Surgery (S.C.Y.);
Department of Pathology (P.C.B.); and Department of Medicine, Division of
Pulmonary and Critical Care (J.B.O.), Johns Hopkins Medical Institutions,
Baltimore, MD 21231; University of Maryland School of Medicine, Baltimore, MD
21201 (B.W.); and Washington University School of Medicine, St. Louis, MO 63110
(A.P.); USA
Donor-acquired solid organ malignancy is a rare complication of organ
transplantation.
We report a case of a patient who received bilateral lung transplants for
pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM).
The lungs, heart, liver, and kidneys were harvested after a lethal intracranial
bleed and accepted for transplantation by four centers.
An enlarged hilar lymph node sampled at the time of transplant was found to
contain GBM.
Four months later, the patient developed diffuse interstitial pulmonary
infiltrates with mediastinal lymphadenopathy.
Lung biopsy confirmed metastatic GBM.
The patient died 2 weeks after the diagnosis was established.
The patient receiving the donor liver also developed GBM.
We present a case study, review of the literature, and suggested interventions
to minimize the risk of transmission.
© 2004 Duke University Press
Source: http://dandini.ingentaselect.com/vl=2858652/cl=89/nw=1/rpsv/cgi-bin/linker?ini=dup_no&reqidx=/cw/dup/15228517/v6n3/s10/p259
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