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Incidence proportions of brain metastases in the Metropolitan
Detroit Cancer Surveillance System (MDCSS) 1973-2001
Jill S. Barnholtz-Sloan, Andrew E. Sloan, Faith G. Davis,
Fawn D. Vigneau, Ping Lai, Raymond E. Sawaya
Wayne State University/Karmanos Cancer Institute, Detroit,
MI, University of Illinois at Chicago School of Public Health, Chicago, IL, MD
Anderson Cancer Center, Houston, TX. E-mail: jbsloan@med.wayne.edu
Objective.
Population-based estimates of the incidence of brain metastases are
not generally available.
The purpose of this study was to calculate
population-based incidence proportions of brain metastases from single primary
lung, melanoma, breast, renal or colorectal cancer.
Materials and Methods.
Patients diagnosed with single primary lung,
melanoma, breast, renal or colorectal cancer (1973-2001) in the Metropolitan
Detroit Cancer Surveillance System (MDCSS) were used for analysis.
Incidence
proportion (IP) of brain metastases by primary site and variable of interest
(race, gender, age at diagnosis of primary cancer and SEER stage of primary
cancer) were calculated with 95% confidence intervals.
Results.
Total IP of brain metastases was 9.6% for all primary sites
combined, highest for lung (19.9%) followed by melanoma (6.9%), renal (6.5%),
breast (5.1%) and colorectal (1.8%) cancers.
Racial differences were seen within
primary site, where African Americans had higher IP of brain metastases compared
to other racial groups for most sites.
IP was significantly higher for females
with lung cancer and significantly higher for males with melanoma.
IP of brain
metastases increased until age 40-49 for primary lung cancer, age 50-59 for
primary melanoma, renal or colorectal cancers and age 20-39 for primary breast
cancer, where it then began to decline.
A significant increase in IP as SEER
stage of primary cancer increased was seen for all primary sites.
Conclusion.
Total IP of brain metastases was lower than previously
reported and it varied by primary site, race, gender, age at diagnosis of
primary cancer and SEER stage of primary cancer.
Copyright © 2004 American Association for Cancer Research. All rights
reserved.
Source: http://aacr04.agora.com/planner/displayabstract.asp?presentationid=762
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