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Etiology and Pathogenesis
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Stem Cells
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Lancet Oncololy, Volume 5, Issue 8, 1 August 2004, Pages 511-514.
Available online 29 July 2004.
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Abstract |
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Development of gliomas: potential role of asymmetrical cell
division of neural stem cells
François Bergera, Emmanuel Gayb,
Laurent Pelletierc, Philippe Tropeld
and Didier Wione
aNeurooncologist, group leader, and professor, University of
Grenoble, Members of the Preclinical Neuroscience Laboratory, INSERM Unit 318,
Grenoble, France; bNeurosurgeon and professor University of
Grenoble, Members of the Preclinical Neuroscience Laboratory, INSERM Unit 318,
Grenoble, France; cAssistant professor, University of Grenoble,
Members of the Preclinical Neuroscience Laboratory, INSERM Unit 318, Grenoble,
France; dPostdoctoral researcher, French association
against Myopathies, Members of the Preclinical Neuroscience Laboratory, INSERM
Unit 318, Grenoble, France; eResearch scientist at INSERM, Members of the
Preclinical Neuroscience Laboratory, INSERM Unit 318, Grenoble, France.
Correspondence: Dr Didier Wion, INSERM
U318, CHU Michallon, 38043 Grenoble, France. Tel: +33 4 7676 5653. Fax: +33 4
7676 5619.
Asymmetrical cell division is a mechanism that gives rise to two daughter cells
with different proliferative and differentiative fates.
It occurs mainly during
development and in adult stem cells.
Accumulating evidence suggests that tumour
cells arise from the transformation of normal stem cells.
Here, we propose that
the asymmetrical mitosis potential of stem cells is associated with the
generation of migrating tumour progenitors.
Application of this speculative
model to glioma proposes that the sites where tumour-initiating stem cells
reside are indolent and distinct from the tumour mass, and implies that the
tumour mass is continuously replenished with new migrating tumour cells from
these clinically silent regions.
This hypothesis offers explanations for our
inability to cure glioblastoma and points to asymmetrical division as a new
potential therapeutic target.
Copyright
© 2004 Elsevier Ltd. All rights reserved.
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