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MR Imaging of Mouse Leptomeningeal
Metastases
Dieta Brandsma, Martin J.B. Taphoorn, Jaap C.
Reijneveld, Thomas M. Nas, Emile E. Voest, Klaas Nicolay, Erwin Blezer
Department
of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands;
Laboratory of Medical Oncology of the Department of Medical Oncology, University
Medical Center Utrecht, Utrecht, The Netherlands (D.B., J.C.R.). Department of
Neurology, University Medical Center Utrecht, Utrecht, The Netherlands (M.J.B.T.,
T.M.N.).Laboratory of Medical Oncology of the Department of
Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
(E.E.V.). Department of Biomedical NMR, Faculty of Biomedical Engineering,
Eindhoven University of Technology, Eindhoven, The Netherlands (K.N.).
Department of Experimental in vivo NMR, Image Sciences
Institute, University Medical Center Utrecht, Utrecht, The Netherlands (E.B.)
To develop new treatment strategies for patients with leptomeningeal
metastases (LM), potential therapeutic agents have to be tested in murine models
first.
In vivo magnetic resonance imaging has an additive value in non-invasive
monitoring of the effects of therapeutic agents on LM.
Previously, we described a reproducible mouse model for B16F-10 melanoma
LM.
In this paper, we visualize leptomeningeal melanoma metastases in mice on both T2
weighted MR images and gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA)
enhanced T1 weighted MR images, using a 4.7T MR spectrometer.
We conclude that both MR sequences can be used to detect and monitor LM of
melanoma cells in mice.
Our data further suggest that LM are more clearly visualized using T1
weighted Gd-DTPA enhanced subtraction imaging than T2 weighted
imaging.
Keywords: leptomeningeal metastases, mouse, MRI
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://journals.kluweronline.com/article.asp?PIPS=5268441
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