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Expression of G-CSF and GM-CSF in Human Meningiomas Correlates with
Increased Tumor Proliferation and Vascularization
Bernhard Braun, Manfred Lange, Reinhard Oeckler,
Margareta M. Mueller
Department of Gastroenterology, Hospital
Darmstadt (B.B.); Department of Neurosurgery, Hospital Villingen-Schwenningen
(M.L., R.O.); Division of Carcinogenesis and Differentiation, German Cancer
Research Center (M.M.M.); Heidelberg, Germany
The hematopoietic growth factors granulocyte- and granulocyte–macrophage
colony stimulating factor (G-CSF and GM-CSF) are nowadays widely used in routine
cancer therapies as potent factors to control radiation and chemotherapy induced
neutropenia, a side effect that frequently endangers the success of tumor
therapies.
However, there is little information about the role of G-CSF and GM-CSF for
tumor growth or progression.
We were interested in the expression and potential role of both factors in human
meningiomas, tumors of arachnoidal origin that account for about 20% of all
primary intracranial tumors.
Therefore, we analyzed immunohistochemically the protein expression of G-CSF,
GM-CSF and their respective receptors in 30 meningioma tissues of different
malignancy and histopathological type.
Both factors and receptors were not expressed in the corresponding normal
tissue.
In contrast, G-CSF, GM-CSF and their receptors were expressed to a varying
degree in human meningiomas.
Increasing expression of both factors and receptors correlated significantly
with enhanced proliferation in the tumor and thus with higher malignancy.
In addition, a strong perivascular expression of G-CSF was associated with a
highly vascularized tumor type.
Thus, expression of both G-CSF and GM-CSF is associated with the expression of
proliferation vascularization, two markers of an increasingly malignant tumor
phenotype, suggesting a contribution of both factors to tumor progression.
Keywords: G-CSF, GM-CSF, Ki-67, meningiomas, proliferation, tumor progression
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://journals.kluweronline.com/article.asp?PIPS=5269312
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