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Importance
of baseline mini-mental state examination as a prognostic factor for patients
with low-grade glioma
Brown PD, Buckner JC, O'Fallon JR, Iturria NL, O'Neill BP, Brown CA,
Scheithauer BW, Dinapoli RP, Arusell RM, Curran WJ, Abrams R, Shaw EG
Mayo Clinic, Rochester, MN, USA.
Purpose. The outcome and cognitive performance data collected in a
prospective, intergroup clinical trial were analyzed to assess the prognostic
importance of the baseline (before radiotherapy) Mini-Mental State Examination
(MMSE) score in patients with low-grade glioma.
Methods
and Materials. The patients studied were 203 adults with a supratentorial low-grade
glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose
(64.8 Gy in 36 fractions) localized radiotherapy.
Folstein MMSE scores and neurologic function scores at baseline in combination
with multiple other baseline variables were analyzed.
The median follow-up was 7.4 years for the 101 patients still alive.
Results. Patients (n = 36) with an abnormal baseline MMSE score (<or=26) had a
worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and
overall survival rate (31% vs. 76%; p <0.001) compared with those with a
normal score.
On multivariate analysis, the baseline MMSE score was a statistically
significant predictor of survival.
Other factors associated with overall survival were age, tumor size, and tumor
histologic type.
Conclusion. The presence of an abnormal baseline MMSE score was a strong predictor
of poorer progression-free and overall survival for patients with a low-grade
glioma. The baseline MMSE should be considered in future prognostic scoring
systems.
PMID: 15093907 [PubMed - in process]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15093907
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