BRAINLIFE Brain Tumor Medical Database

Integrative Medicine Antineoplastons  


Integr Cancer Ther. 2004 Mar;3(1):47-58. (Review Article)


Abstract

The present state of antineoplaston research (1)

Burzynski SR

Burzynski Research Institute, Houston, TX 77055, USA. info@burzynskiclinic.com

Antineoplastons work as molecular switches, which regulate expression of genes p53 and p21 through demethylation of promoter sequences and acetylation of histones. 
They also inhibit the uptake of growth-critical amino acids, such as 1-glutamine and 1-leucine in neoplastic cells. 
Phase II trials indicate efficacy of antineoplastons in low-grade glioma, brain stem glioma, high-grade glioma, adenocarcinoma of the colon, and hepatocellular carcinoma. 
The best results were observed in children with low-grade glioma, where 74% of patients obtained objective response, and in patients with adenocarcinoma of the colon with liver metastases whose survival rate of more than 5 years is 91% versus 39% in controls on chemotherapy. 
Gene array studies will explain antineoplaston-induced changes in gene expression.

PMID: 15035876 [PubMed - indexed for MEDLINE]

Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15035876


 

This website is certified by Health On the Net Foundation. Click to verify. HOMEARCHIVES OF NEURO-ONCOLOGYCURRENT NEURO-ONCOLOGYGLIOBLASTOMA REPORTS
SERVICES: About BrainLife | Brain Tumor Medical Database | Children's Corner | Dedication | E-mail Alerts | Journals | Privacy Policy | Publications

This site complies with the HONcode standard for trustworthy health information: verify here bottom