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Results
of whole brain radiotherapy and recursive partitioning analysis in patients with
brain metastases from renal cell carcinoma: a retrospective study
Cannady SB, Cavanaugh KA, Lee SY, Bukowski RM, Olencki TE, Stevens GH,
Barnett GH, Suh JH
Otolaryngology, Brain Tumor Institute, Cleveland Clinic
Foundation, Cleveland, OH, USA
To determine the benefit of whole brain radiotherapy (WBRT) and the use of the
Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA)
classification system in patients with brain metastases from renal cell
carcinoma.
We identified 46 consecutive patients with brain metastases from renal cell
carcinoma who were treated with WBRT at the Cleveland Clinic Foundation between
1983 and 2000.
We reviewed their charts for patient and tumor characteristics and categorized
them according to the RTOG RPA classes.
The median follow-up and survival time for all 46 patients (15 women and 31 men)
was 3.0 months.
The median radiation dose was 3000 cGy in 10 fractions.
Patients who received higher radiation doses (>3000 cGy) survived longer than
those who received 3000 cGy or less than 3000 cGy (8.5 months vs. 2.7 months vs.
0.4 months, p = 0.0289).
However, the Karnofsky performance status and RPA class were confounding factors
in these data.
The median survival for patients by RTOG RPA class was 8.5 months for Class I (n
= 2), 3 months for Class II (n = 37), and 0.6 months for Class III (n = 7, p =
0.0834).
Despite the relatively poor prognosis of patients who receive WBRT alone, it
appears that they benefit from this palliative treatment.
The RTOG RPA classification system may be a useful tool in assessing prognosis
in this patient population.
PMID: 14697446 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14697446&dopt=Abstract |
