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Pituitary stalk thickening and primary central nervous system
lymphoma
Capra M, Wherrett D, Weitzman S, Dirks P, Hawkins C, Bouffet E.
Division of Haematology/Oncology, Hospital for Sick Children,
Toronto, Canada. michael.capra@sickkids.ca
We report a 14-year-old girl in whom a diagnosis of primary central nervous
system lymphoma was confirmed while receiving growth hormone (GH) for GH
deficiency, detected after presenting with short stature.
MRI revealed an enhancing and thickened pituitary stalk with absence of the
normal bright signal in the posterior pituitary.
Regular MRI surveillance detected progression of the neurohypophyseal changes 13
months into GH treatment.
Biopsy confirmed this to be B-cell large cell lymphoma.
This case highlights the diagnostic and management challenges inherent in
treating such children.
PMID: 15072472 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15072472
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