|
|
Immediate post-radiotherapy changes in malignant glioma can
mimic tumor progression
De Wit MC, De Bruin HG, Eijkenboom W, Sillevis Smitt PA, Van Den Bent MJ.
Department of Neuro-oncology/Neurology, Daniel den Hoed Cancer Center/Erasmus
Medical Center, PO Box 5201, 3008 AE Rotterdam, The Netherlands.
m.vandenbent@erasmusmc.nl
To determine the frequency of progressive MRI lesions shortly after radiotherapy
for glioma with spontaneous improvement or stabilization, the authors studied a
cohort of patients treated within two prospective phase III trials with
radiotherapy only.
In 9 out of 32 patients, the first post-radiotherapy MRI
showed progressive enhancement.
In 3 of these 9 the MRI improved or stabilized
for 6 months without additional treatment.
The authors conclude that patients
with progressive lesions within 3 months after radiotherapy should not be
eligible for phase II trials on recurrent glioma.
PMID: 15304589 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15304589
|
