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[Contribution
of PET to the management of patients with low-grade glioma]
[Article in French]
De Witte O, Oulad Ben Taib N, Branle F, Rorive S, Brotchi J,
Goldman S
Service de Neurochirurgie (Clinique Neurochirurgicale d'Oncologie),
odewitte@ulb.ac.be
Background and Purpose. Management of patients with
low-grade glioma is a major challenge for the neurosurgeon.
When
is neurosurgery indicated?
Should
chemotherapy or radiotherapy be used?
Many
questions without an answer.
We
reviewed our experience with 65 patients treated for low-grade glioma
who had preoperative PET images (FDG or/and MET).
We
examined the prognostic value of PET and also determined the
sensitivity and the specificity of PET images to predict
outcome.
Methods.
Sixty-five patients with a FDG or MET PET images were analyzed.
We
used two visual scales and had complete follow-up data for 63
patients.
The
free interval was the principal criterion for statistical
analysis.
The
sensitivity and the specificity of PET images was determined.
Results.
Strong FDG uptake was correlated with a short free interval
(p=0.001).
Similar
results were found with the MET analysis (p=0.0076).
We
had a PET with MET and FDG for 36 patients.
The
sensitivity was 66% and the specificity 94% for FDG PET.
Sensitivity
was 100% and specificity 53% for MET PET.
Conclusion.
PET imaging provides a prognostic factor independent from
histology.
MET
PET is the best exam for the follow-up of patients with low-grade
glioma and is helpful for separating aggressive from low-grade glioma.
PMID: 15547485 [PubMed - in process]
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