|
|
Loss of 14q Chromosome in
Oligodendroglial and Astrocytic Tumors
Charles Dichamp,
Sophie Taillibert, Lucinda Aguirre-Cruz, Julie Lejeune, Yannick Marie, Michèle
Kujas, Jean-Yves Delattre, Khe Hoang-Xuan and Marc Sanson
Unité INSERM U495 (C.D.,
L.A.-C., Y.M., J.-Y.D., K.H.-X, M.S.), Fédération de Neurologie Mazarin (S.T.,
J.L., M.K., J.-Y.D., K.H.-X, M.S.), Laboratoire de Neuropathologie R Escourolle
(Pr Hauw) (M.K.), Hôpital de la Salpêtrière, Universit Pierre et Marie Curie,
Paris, France; Instituto Nacional de Neurologia y Neurocirugia, Mexico D.F,
Mexico (L.A.-C.)
Loss of chromosome 14q has been investigated in 142 gliomas.
Loss of heterozygosity (LOH) at one or more microsatellite has been found in
8/30 grade II (27%) and 2/21 grade III (10%) oligodendrogliomas, 3/9 grade II
(33%) and 5/15 grade III (33%) oligoastrocytomas, 0/9 grade II (0%) and 1/7
grade III (14%) astrocytomas, 11/51 glioblastomas (22%).
Two minimal regions were identified on 14q21.2–14q24.3
(between D14S288 and D14S74) and 14q31.3–14q32.1
(between D14S74 and D14S65).
Loss of 14q was not correlated to survival, histological grading and subtype or
other genetic alterations, except for 1p deletions.
Taken together, these data suggest that LOH14q is an early alteration involving
20% of glioma.
Keywords: chromosome
14q, glioma, oligodendroglioma, glioblastoma
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://journals.kluweronline.com/article.asp?PIPS=5266133
|
