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Preferential brain locations of
low-grade gliomas
Duffau H, Capelle L
Department of Neurosurgery, Hopital Salpetriere, Paris, France.
hugues.duffau@psl.ap-hop-paris.fr
Background. The
objectives of this study were to register the brain locations in a consecutive
series of low-grade gliomas (LGGs) and compare these localizations with the
locations of de novo glioblastomas (GBMs) that were collected during the same
period in an effort to analyze whether LGGs are situated in preferential areas
and to review the pathophysiologic hypothesis of such a phenomenon.
Methods. One hundred
thirty-two patients with LGG and 102 patients with GBM who were followed
consecutively between 1996 and 2003 by the authors were reviewed, whatever their
treatment.
Using anatomic, three-dimensional magnetic resonance imaging, the location of
each tumor was analyzed accurately according to a classification system based on
the proximity of eloquent areas previously reported by the authors.
Results. One hundred
nine LGGs (82.6%), compared with 55 GBMs (53.9%), were situated within
functional regions (P < 0.001).
More specifically, 36 LGGs (27.3%), compared with 11 GBMs (10.8%), were
localized in the region of the supplementary motor area (SMA) (P < 0.001);
and 33 LGGs (25%), compared with 11 GBMs (10.8%), were located within the insula
(P < 0.001).
Conclusions. The current
findings suggest that LGGs are located preferentially in "secondary"
functional areas (immediately near the so-called primary eloquent regions),
especially within the SMA and the insular lobe.
This preferential localization may be explained by developmental,
cytomyeloarchitectonic, neurochemical, metabolic, and functional reasons.
A better knowledge of the pathophysiologic mechanisms underlying preferential
LGGs locations may improve understanding of the genesis and natural history of
these tumors and, subsequently, their management.
Copyright 2004 American Cancer Society.
PMID: 15197805 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15197805
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