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High and Low Grade Oligodendrogliomas
(ODG): Correlation of Amino-Acid and Glucose Uptakes Using PET and Histological
Classifications
F. Giammarile, L.E. Cinotti, A. Jouvet, J.M. Ramackers, G.
Saint Pierre, P. Thiesse, E. Jouanneau, J. Guyotat, I. Pelissou-Guyotat, A.
Setiey, J. Honnorat, D. Le Bars, D. Frappaz
Service
de Médecine
Nucléaire, Centre Léon
Bérard, Lyon, France (F.G,
P.T., D.F.); Centre d'Exploration et de Recherche Médicale par Emission de Positons (CERMEP), Lyon, France (L.E.C.,
D.L.B.); Hôpital
Neurologique, Lyon, France (A.J.,
G.S.P., E.J., J.G., I.P.-G., J.H.); Imagerie Nucléaire
de l'Ouest Lyonnais (INOL), Lyon, France (J.M.R.);
Hôpital
de Villefranche, France (A.S.)
Classification and treatment strategy of Oligodendrogliomas (ODG) remain
controversial.
Imaging relies essentially on contrast enhancement using CT or MRI.
The aim of our study was to use positron emission tomography (PET) using
[18F]-flurodeoxyglucose (FDG) and [11C]-L-methyl-methionine (MET) to
evaluate metabolic characteristics of (ODG).
We studied 19 patients with proven ODG, comparing standardised uptake values
(SUV) and maximal tumor/contralateral normal tissues ratios (T/N).
Imaging findings were compared with WHO, Smith and Daumas–Duport
classifications.
Uptake of FDG was decreased only in 8 patients, independently of grading, while
MET uptake was always increased.
MET uptake was significantly higher for high grade tumors grouped according to
Smith or Daumas–Duport classifications, while
no significant difference in MET uptake was found when using WHO
classification.
A different correlation was found between FDG and MET uptakes in normal tissues
and high grade tumors.
A trend for improved progression free survival was found for tumors that lacked
contrast enhancement on MRI or those showing low FDG or MET uptake.
In conclusion, MET appeared more sensitive than FDG to detect proliferation in
ODG.
The preferential protein metabolism, already noticeable for low-grade tumor,
correlated with glucose metabolism and helped to separate, in vivo,
high and low grade tumors.
Keywords: C11-methionine, F18-fluorodeoxyglucose, histopathological classification,
oligodendroglioma, positron emission tomography
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://ipsapp009.kluweronline.com/IPS/content/ext/x/J/5042/I/119/A/10/abstract.htm
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