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Intracranial
Meningiomas Developing at Long Intervals Following Low-Dose X-Ray Irradiation of
the Head
Georg Gosztonyi, Felicia Slowik, Emil Pásztor
Department
of Neuropathology, Freie Universität Berlin, University Clinics Benjamin Franklin,
Hindenburgdamm 30, D-12200 Berlin, Germany; Tel.: +49-30-792-3437; E-mail: gegos@zedat.fu-berlin.de
[G.G.]. National Institute of Neurosurgery, Budapest, Hungary
[F.S., E.P.].
Five
patients are reported who underwent X-ray epilation in childhood for tinea
capitis and who developed meningiomas after about four decades.
X-ray irradiation resulted in permanent alopecia in four of the five
patients.
In four patients the tumors were found on the convexity, one patient had a
tuberculum sellae meningioma.
All five patients underwent surgery.
Recurrence was noted in three of the five patients, one of them was
reoperated.
No malignant features, but signs of atypia were found at histopathological
examination.
The development of meningiomas after low-dose irradiation with long latency
periods, the predominant calvarial location of the tumors, the high recurrence
rates, the absence of malignant traits but the presence of atypias are features
overwhelmingly common with similar cases published in the literature.
The fact that two of the five patients were sisters stresses the importance of
genetic factors in the evolution of these tumors.
Keywords: alopecia,
epilation, intracranial tumors, radiation-induced meningioma, tinea capitis,
X-ray therapy
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://ipsapp009.kluweronline.com/IPS/content/ext/x/J/5042/I/123/A/4/abstract.htm
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