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CD44 expression
and tumour cell density correlate with response to tamoxifen/carboplatin
chemotherapy in glioblastomas
Christian Hagel, Sung-Ho Park,
Maximilian J.A. Puchner and Dimitrios Stavrou
Institute of
Neuropathology, University Klinicum Hamburg-Eppendorf, Hamburg (C.H., S.-H.P.,
D.S.); Clinic of Neurosurgery, Krankenanstalten Gilead GmbH, Bielefeld, Germany
(M.J.A.P.).
In order to identify response
predictors for a post-operative glioblastoma therapy consisting of tamoxifen,
carboplatin for
CD44s, TGF-β2, TGF-α,
progesterone receptor, estrogen receptor, EGFR, urokinase, urokinase inhibitor
1, CD87, p53 protein and
Ki-67.
Vessel density was determined by labelling of endothelia with von Willebrand
Response to chemotherapy correlated positively with cell density (p
< 0.05)
and negatively with CD44 overexpression
In tumour recurrences expression of CD44 was
significantly higher in local recurrences than in distant multifocal recurrences
(p < 0.02),
suggesting that CD44 may predominantly be associated with cell adhesion in
glioblastomas.
Key words: CD44,
carboplatin, glioblastoma, p53, tamoxifen, urokinase
©2004 Kluwer
Academic Publishers. Printed in the Netherlands.
Source: doi:10.1023/B:NEON.0000013496.58236.f0
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