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Cerebellar malignant fibrous histiocytoma: case report and
literature review
Hamlat A, Adn M, Caulet-Maugendre S, Guegan Y
Department of Neurosurgery, Centre Hospitalier Regional Universitaire
Pontchaillou, Rennes, France. hamlat.abd@wanadoo.fr
Objective and importance. Malignant fibrous histiocytoma in the central nervous
system is uncommon.
Fewer than 70 cases have been documented and, to the best of
our knowledge, this is the first case arising from the cerebellum.
Clinical presentation.
A 44-year-old woman presented with headaches, vomiting, and
dizziness.
A neurological examination revealed right cerebellar syndrome.
Brain
computed tomographic scans revealed an isodense tumor in the right cerebellar
hemisphere.
The breast ultrasonographic, bone scintigraphic, and
thoracoabdominal computed tomographic findings were normal.
Intervention. The
patient was surgically treated.
The tumor recurred 1.5 months later,
demonstrating hemorrhagic characteristics on brain computed tomographic scans.
The patient underwent a second operation, followed by radiotherapy.
Conclusion. Malignant fibrous histiocytoma is still a controversial entity, and the lack of
specific criteria means that it must be diagnosed via the process of
elimination.
With currently available therapy, our review can provide only a
very poor prognosis.
The median survival time was 27 months.
In attempts to
develop better therapeutic strategies, total excision and radiotherapy seem to
represent the best treatment approach.
PMID: 15028153 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15028153
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