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Meningioma and schwannoma risk in adults in relation to family history of
cancer
Deirdre A. Hill, Martha S. Linet, Peter M. Black, Howard A. Fine, Robert G.
Selker, William R. Shapiro, and Peter D. Inskip
Division of Cancer Epidemiology and Genetics (D.A.H., M.S.L.,
P.D.I.) and Neuro-Oncology Branch (H.A.F.), National Cancer Institute, National
Institutes of Health, Department of Health and Human Services, Bethesda, MD
20892; Department of Neurosurgery, Brigham and Women’s Hospital, Boston, MA
02115 (P.M.B.); Division of Neurosurgery, Western Pennsylvania Hospital,
Pittsburgh, PA 15224 (R.G.S.); and Department of Neurology, Barrow Neurological
Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ 85013
(W.R.S.); USA.
Relatively little is known about factors that contribute to the development
of meningioma and vestibular schwannoma, two intracranial nervous system
tumors.
We evaluated the risk of these tumors in relation to family history of malignant
or benign tumors.
Incident cases of meningioma (n = 197) or schwannoma (n = 96) were identified at
three U. S. referral hospitals between June 1994 and August 1998.
Controls (n = 799) admitted to the same hospitals for nonmalignant conditions
were matched to cases on age, sex, race/ethnicity, hospital, and proximity of
residence to hospital.
We found that risk of meningioma was increased among persons reporting a family
history of a benign brain tumor (odds ratio [OR], 4.5; 95% confidence interval
[CI], 1.0-21.0; n = 5) or melanoma (OR, 4.2; 95% CI, 1.2-15.0; n 5).
A family history of breast cancer was associated with an elevated meningioma
risk among participants aged 18 to 49 years (OR, 3.9; 95% CI, 1.4-11.0; n = 8)
but a reduced risk among older respondents (OR, 0.2; 95% CI, 0.1-0.7; n =
3).
Family history of cancer did not differ between schwannoma cases and controls,
although the statistical power to detect associations was limited.
Some relative risk estimates were based on a small number of observations and
may have arisen by chance.
Inheritance of predisposing genes, shared environmental factors, or both within
families with a history of benign brain tumors, melanoma, or possibly breast
cancer may be related to altered meningioma risk.
© 2004 Duke University Press
Source: http://lysander.ingentaselect.com/cgi-bin/linker?ini=dup_no&reqidx=/cw/dup/15228517/v6n4/s2/p274
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