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Molecular pathogenesis of astrocytic tumours
Koichi
Ichimura, Hiroko Ohgaki, Paul Kleihues, V. Peter Collins
Department
of Pathology, University of Cambridge, Cambridge, UK [K.I., V.P.C.]. The
International Agency for Research on Cancer, Lyon, France [H.O., P.K.].
Our
current knowledge of the molecular pathogenesis of the diffuse adult astrocytic
tumours is vast if compared to 20 years ago, yet we are far from understanding
the details of this process at the molecular level and using such an
understanding to logically and specifically treat patients' tumours.
In other astrocytic tumours we have little or no knowledge of the molecular
processes.
This article will attempt to summarise the histological classification criteria
and genetic data for all the astrocytic tumours.
The current World Health Organisation classification lists six entities, some
with subgroups.
Common problems associated with the diagnosis of these tumours are
outlined.
While the molecular findings are not as yet used clinically, we are approaching
a time when the histological investigation will have to be supplemented with
molecular data to ensure the best choice of treatment for the patient and as an
accurate indicator of prognosis.
Keywords:
anaplastic
astrocytoma, astrocytoma, glioblastoma, glioma, microarray, p53 pathway, Rb1
pathway, secondary glioblastoma
Copyright
©
2004 Kluwer Academic Publishers.
All
rights reserved
Source: http://ipsapp007.kluweronline.com/IPS/content/ext/x/J/5042/I/125/A/3/abstract.htm
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