|
|
The cell cycle: accelerators, brakes, and
checkpoints
Ivanchuk SM, Rutka JT
Division of Neurosurgery and the Arthur and Sonia Labatt Brain
Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Proliferative cues trigger a complex series of molecular signaling events in
cells.
Early in the cell cycle, cells are faced with an important decision that affects
their fate.
They either initiate a round of replication or they withdraw from cell
division.
Passage through the restriction point, or "point of no return," marks
cellular commitment to a new round of division.
Genetic mutations that predispose individuals to tumorigenesis often affect
pathways that influence cellular proliferation.
Many of the mutated genes give rise to molecules that are no longer able to
appropriately regulate the mammalian cell cycle; the end result is
neoplasia.
In this review, the critical elements that permit cell cycle progression and the
positive and negative regulators that affect the process are reviewed.
PMID: 15028146 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15028146
|
