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Spinal Cord Gangliogliomas: A Review of 56 Patients
George I. Jallo, Diana Freed, Fred J. Epstein
Johns
Hopkins University School of Medicine, Division of Pediatric Neurosurgery,
Baltimore, MD (G.I.J.);
Institute for Neurology and Neurosurgery, Beth Israel
Medical Center, NY, USA (D.F.,
F.J.E.)
There have been only case reports concerning the management of
intramedullary spinal cord gangliogliomas.
We review our experience of 56 patients with respect to functional status,
progression-free survival and long-term outcome.
In this retrospective review, 56 patients, 35 males and 21 females ranging in
age from 7 months to 25 years (mean, 7.0 y),
underwent surgical treatment for intramedullary gangliogliomas located
throughout the spinal cord.
Forty-six patients had gross total resection as confirmed by postoperative
imaging studies, and 10 had radical subtotal resection.
Only five patients underwent postoperative irradiation or chemotherapy after
surgery at our center and therefore outcome was attributed to surgery
alone.
There were no operative deaths, and the 5-year actuarial survival rate was
88%.
The progression-free survival rate at 5 years was 67%.
Neurological function in the surviving patients at recent follow-up evaluation
was stable or improved in 72%.
Patients have a long survival following radical surgery.
These tumors have an indolent course, and radiotherapy appears to be
unnecessary.
Keywords: ganglioglioma, intramedullary neoplasm, outcome, radiation therapy spinal
cord tumor, surgery
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source:
http://journals.kluweronline.com/article.asp?PIPS=5268436
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