The expression of survivin and Ki-67 in
meningiomas: correlation with grade and clinical outcome
Kayaselcuk F, Zorludemir S, Bal N, Erdogan B, Erdogan S, Erman T
Department of Pathology, Faculty of Medicine, Adana Teaching and
Medical Research Center, Baskent University, Turkey.
Identification of proteins involving in the control of proliferation in normal
cells may lead to a better understanding of cellular transformation and
Measurement of proliferative activity may help determine the tumor grade,
recurrence and malignancy.
Forty meningiomas of various histological grade, diagnosed in Baskent University
and Cukurova University Medical Faculty, Departments of Pathology, were graded
according to WHO grading system and survivin and Ki-67 monoclonal antibodies
were administered by immunohistochemical method.
Findings were analyzed with statistical methods; distribution of survivin
expression and Ki-67 LI values were determined for different grade
The correlation between increasing grades of meningiomas, particularly between
grades I and III, survivin and Ki-67 LI values was statistically
In addition, we have found a positive correlation between clinical outcome,
survivin and Ki-67 LI.
For over expression of survivin in some of the grade I meningiomas and no or
mild expression in some of the grades II and III meningiomas, however, it has
been suggested that apoptosis inhibited by survivin is not the only factor
responsible for progression of meningiomas.
PMID: 15072469 [PubMed - indexed for MEDLINE]