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Correlations
between molecular profile and radiologic pattern in oligodendroglial
tumors
Laigle-Donadey
F, Martin-Duverneuil N, Lejeune J, Criniere E, Capelle L, Duffau H,
Cornu P, Broet P, Kujas M, Mokhtari K, Carpentier A, Sanson M,
Hoang-Xuan K, Thillet J, Delattre JY
Federation
de Neurologie Mazarin, Groupe Hospitalier Pitie-Salpetriere, Paris,
France.
Objective.
To investigate possible correlations between tumor location and
genetic alterations in a series of oligodendrogliomas.
Methods.
A series of 158 consecutive oligodendrogliomas were retrospectively
reviewed.
In each case, the radiologic picture and the chromosome 1p (chr 1p)
status of the tumor detected by the loss of heterozygosity technique
were analyzed.
Correlation between tumor location and molecular profile was made by
chi2 tests.
Results.
Eighty-eight of the 158 patients had low-grade oligodendrogliomas, and
70 had anaplastic oligodendrogliomas.
Overall, oligodendrogliomas with chr 1p loss were located
preferentially in the anterior part of the brain, whereas tumors with
intact chr 1p affected mainly the posterior part of the brain (p =
0.0038).
In terms of lobar involvement, a preferential location of
oligodendrogliomas with chr 1p loss was found in the frontal lobes as
compared with the temporal, parietal, and occipital tumors (p <
0.01).
Conclusion.
There is a significant correlation between loss of heterozygosity on
chromosome 1p and tumor location in oligodendrogliomas, suggesting
that subtypes of oligodendrogliomas could derive from site-specific
precursors.
PMID: 15623700 [PubMed - in process]
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