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Presentation and outcome of 93 cases of
craniopharyngioma
Larijani B, Bastanhagh MH, Pajouhi M, Kargar Shadab F, Vasigh A, Aghakhani S
Endocrinology and Metabolism Research Center, Tehran University
of Medical Sciences, Tehran, Iran. emrc@sina.tums.ac.ir
We studied a series of 93 patients diagnosed with craniopharyngioma during a
15-year period with respect to presenting symptom, clinical course and
management.
The majority (62%) of patients were men, and had presented with neurological
symptoms (75%), with headaches (82%) being the most common presenting
symptom.
The incidence of certain endocrine and ophthalmic symptoms varied little from
that in the literature, on the other hand, the incidence of certain other
symptoms did differ markedly from the literature.
For example, loss of libido and amenorrhoea were seen at a much lower frequency
than that stated in the literature.
Hypertension, sensorimotor symptoms and urinary incontinence were not seen at
all in our patients.
In most cases diagnosis was made by a cranial CT scan, which is more sensitive
than plain radiography for detection of enlarged sella turcica (69% vs. 24%; P
< 0.001).
In over 90% of cases, therapy consisted of removal of a variable portion of the
tumour, with or without radiotherapy.
Post-operative mortality was substantially reduced in cases treated by
radiotherapy (P < 0.05).
The most common post-operative complications in all cases were recurrence of
disease, panhypopituitarism and diabetes insipidus.
PMID: 14961770 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14961770
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