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Correlation between clinical characteristics and
proliferative activity in patients with craniopharyngioma
Losa M, Vimercati A, Acerno S, Barzaghi RL, Mortini P, Mangili F, Terreni
MR, Santambrogio G, Giovanelli M
Pituitary Unit, Department of Neurosurgery, Istituto Scientifico San
Raffaele, University Vita-Salute, Milan, Italy. Department of Pathology,
Istituto Scientifico San Raffaele.
Objectives. The aim of the study was to correlate the Ki-67 and cyclin A
labelling index (LI) with clinical characteristics and risk of recurrence of
craniopharyngiomas.
Methods. 47 consecutive patients were studied, 21 female
and 26 male, aged 34.3 (2.8) years.
Immunohistochemical analysis was
performed on paraffin wax embedded material using monoclonal antibodies
directed against the proliferation associated nuclear antigen Ki-67 and
cyclin A.
Results. The median Ki-67 LI was 8.6% (interquartile range,
4.4%-14.0%).
Ki-67 LI was significantly higher in tumours with a heavy
inflammatory reaction and diabetes insipidus at presentation, whereas other
clinical and histological features were not associated with the
proliferation index.
There was a strong linear correlation between Ki-67 LI
and cyclin A LI (r = 0.77; p<0.0001); therefore, cyclin A LI showed the
same clinical and histological relations described for Ki-67 LI.
Recurrence
of craniopharyngioma occurred in 13 of 46 patients (28.3%).
The median Ki-67
LI in the 13 recurrent craniopharyngiomas (9.0%) was not significantly
different from that of non-recurring tumours (7.9%).
Cyclin A LI was also
not associated with the risk of relapse.
Conclusions. This study confirms
the great variability of proliferative activity in craniopharyngiomas.
Ki-67
and cyclin A LIs were associated with the presence of a heavy inflammatory
reaction and diabetes insipidus, but did not correlate with the long term
risk of tumour regrowth.
PMID: 15146007 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15146007&dopt=Abstract
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