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Remission of a chiasmatic glioma in a non-NF1
patient after brief chemotherapy with vincristine and carboplatin: case report
and literature review
Elpis Mantadakis, Maria Raissaki, Vassiliki
Danilatou, Alexander Kambourakis, Eftichia
Stiakaki and Maria Kalmanti
Department of Pediatric
Hematology/Oncology [E.M., V.D., A.K., E.S., M.K.], Department of Radiology [M.R.], University Hospital of Heraklion, Heraklion, Crete, Greece.
We describe the case of an 8-year-old girl without neurofibromatosis, who
presented with total loss of vision on the left eye, due to a chiasmatic mass
with imaging characteristics of glioma, accompanied by a second asymptomatic
mass in the middle cranial fossa, along the intracranial route of the right
trigeminal nerve.
The patient received a total of 10 weekly injections of vincristine and four
injections of carboplatin every 3 weeks and achieved a very good partial
response (97% volume reduction) after the nineth week of therapy with acceptable
toxicity.
Given the natural history of opticochiasmatic gliomas, we cannot rule out the
possibility of a spontaneous regression.
However, we believe the quick response accompanied by visual improvement was
most likely due to chemotherapy.
A trial of vincristine and carboplatin may be worthwhile in children with
symptomatic chiasmatic gliomas, irrespective of their age.
PMID: 15072453 [PubMed]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15072453
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